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Recombinant Ebolavirus BDBV(subtype Bundibugyo,strain Uganda 2007) Small/secreted Glycoprotein (sGP) protein, His-tagged

Cat.No. : GP-27B
Product Overview : Recombinant Ebolavirus BDBV(subtype Bundibugyo,strain Uganda 2007) Small/secreted Glycoprotein (sGP) protein (Ile33-Arg324), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).
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  • Gene Information
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Description : EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly. GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.
Source : HEK293
Species : Ebolavirus (subtype Bundibugyo,strain Uganda 2007)
Tag : His
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 34.3 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE).
Protein length : 292
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : GP
Official Symbol : GP
Synonyms : BDBVp4
Gene ID : 9487265
Protein Refseq : YP_003815436.1
UniProt ID : B8XCN1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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