|Product Overview:||Recombinant Cynomolgus TIGIT(Met 89 - Ile 209 ) fused with a human IgG1 Fc tag at C-terminal was expressed in HEK293.|
|Description:||T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.|
|Predicted N Terminal:||Met 89|
|Form:||Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Trehalose is added as protectant before lyophilization.|
|Molecular Mass:||Has a calculated MW of 40 kDa, the reducing (R) protein migrates as 40-50 kDa, and the non-reducing (NR) protein migrates as 80-116 kDa in SDS-PAGE.|
|Protein length:||Met 89 - Ile 209|
|Endotoxin:||Less than 1.0 EU per μg by the LAL method.|
|Purity:||>95% as determined by SDS-PAGE.|
|Storage:||Avoid repeated freeze-thaw cycles.
No activity loss was observed after storage at:
In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).
|Gene Name:||TIGIT T-cell immunoreceptor with Ig and ITIM domains [ Macaca fascicularis ]|
|Synonyms:||TIGIT; T-cell immunoreceptor with Ig and ITIM domains|
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