Recombinant Cynomolgus/Rhesus macaque CD86 protein, His-tagged (HPLC-verified)
Cat.No. : | CD86-172C |
Product Overview : | Recombinant Cynomolgus/Rhesus macaque CD86 protein (Ala19-His240), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).In the region Ala19-His240, the AA sequence of Cynomolgus and Rhesus macaque CD86 are homologus. |
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Description : | Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy. |
Source : | HEK293 |
Species : | Cynomolgus/Rhesus macaque |
Tag : | His |
Form : | Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 27.3 kDa. The protein migrates as 50-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 222 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | CD86 |
Official Symbol : | CD86 |
Synonyms : | CD86; CD86 molecule; CD28LG2, CD86 antigen (CD28 antigen ligand 2, B7 2 antigen); T-lymphocyte activation antigen CD86; B lymphocyte antigen B7 2; B7 2; B7.2; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); B70; B7-2; LAB72; CD28LG2; MGC34413 |
Gene ID : | 102147235 |
mRNA Refseq : | XM_005547997.2 |
Protein Refseq : | XP_005548054.1 |
UniProt ID : | G7NXR4 |
Products Types
◆ Recombinant Protein | ||
CD86-0875H | Recombinant Human CD86 Protein, GST-Tagged | +Inquiry |
CD86-186H | Recombinant Human CD86 Protein, C-His-tagged | +Inquiry |
CD86-592C | Recombinant Cynomolgus monkey CD86 Protein | +Inquiry |
CD86-422H | Recombinant Human CD86 Protein (Met1-His239), His-Fc-tagged, Biotinylated | +Inquiry |
CD86-176H | Recombinant Human CD86 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CD86-1013CCL | Recombinant Cynomolgus CD86 cell lysate | +Inquiry |
CD86-2598MCL | Recombinant Mouse CD86 cell lysate | +Inquiry |
CD86-2619HCL | Recombinant Human CD86 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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