Recombinant HCoV-NL63 Spike Trimer (S1+S2), C-His-tagged
| Cat.No. : | Spike-02H |
| Product Overview : | Human Coronavirus NL63 Spike trimer (S1+S2) (HCoV-NL63 S protein), Genbank Accession No. APF29071, a.a. 1-1296(full length), with a C-terminal His-tag, expressed in a HEK293 expression system. MW=146 kDa. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation. |
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| Description : | S1 region attaches the virion to the cell membrane by interacting with the host receptor, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. |
| Source : | HEK293 |
| Species : | HCoV-NL63 |
| Tag : | C-His |
| Form : | Aqueous buffer solution. |
| Molecular Mass : | 146 kDa |
| AA Sequence : | 1-1296(full length) |
| Purity : | >90% |
| Usage : | Thaw on ice and gently mix prior to use. DO NOT VORTEX. Perform a quick spin before opening. Aliquot into small volumes and flash freeze for long term storage. Avoid multiple freeze/thaw cycles. |
| Storage : | At least 6 months at -80 centigrade. |
| Storage Buffer : | 8 mM phosphate pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol. |
| Shipping : | -80 centigrade |
| Warning : | Avoid freeze/thaw cycles. |
| Official Symbol : | S |
| Synonyms : | S; Spike glycoprotein; S glycoprotein; E2; Peplomer protein |
| UniProt ID : | A0A1L2YVI8 |
| Official Symbol : | S |
| Synonyms : | S; Spike glycoprotein; S glycoprotein; E2; Peplomer protein |
| UniProt ID : | A0A1L2YVI8 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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