Recombinant Human A2M Protein, MYC/DDK-tagged

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Recombinant Human A2M Protein, MYC/DDK-tagged

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Cat.No. : A2M-242H
Product Overview : Recombinant human A2M protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.
Description : Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. [UniProtKB/Swiss-Prot Function]
Source : HEK293
Species : Human
Tag : MYC/DDK
Form : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
Molecular Mass : 160.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : alpha-2-macroglobulin [ Homo sapiens ]
Official Symbol : A2M
Synonyms : A2MD; CPAMD5; FWP007; S863-7
Gene ID : 2
mRNA Refseq : NM_000014.4
Protein Refseq : NP_000005.2
MIM : 103950
UniProt ID : P01023

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