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Recombinant Human ACO2 Protien, His-tagged

Cat.No. : ACO2-095H
Product Overview : Recombinant Human ACO2 Protien(NP_001089)(1-300 aa), fused to His tag, was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : His
Form : The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.). 5 % trehalose and 5 % mannitol are added as protectants before lyophilization.
Protein length : 1-300 aa
AA Sequence : MAPYSLLVTRLQKALGVRQYHVASV LCQRAKVAMSHFEPNEYIHYDLLEK NINIVRKRLNRPLTLSEKIVYGHLD DPASQEIERGKSYLRLRPDRVAMQD ATAQMAMLQFISSGLSKVAVPSTIH CDHLIEAQVGGEKDLRRAKDINQEV YNFLATAGAKYGVGFWKPGSGIIHQ IILENYAYPGVLLIGTDSHTPNGGG LGGICIGVGGADAVDVMAGIPWELK CPKVIGVKLTGSLSGWSSPKDVILK VAGILTVKGGTGAIVEYHGPGVDSI SCTGMATICNMGAEIGATTSVFPYN
Purity : 90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
Storage : Short-term storage: Store at 2-8°C for (1-2 weeks).
Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
Reconstitution : Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage (see Stability and Storage for more details).
If a different concentration is needed for your purposes please adjust the reconstitution volume as required (please note: the ion concentration of the final solution will vary according to the volume used).
Note: Centrifuge vial before opening. When reconstituting, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution.
Gene Name : ACO2 aconitase 2, mitochondrial [ Homo sapiens ]
Official Symbol : ACO2
Synonyms : ACO2; aconitase 2, mitochondrial; aconitate hydratase, mitochondrial; ACONM; citrate hydro-lyase; ICRD; MGC20605; MGC33908;
Gene ID : 50
mRNA Refseq : NM_001098
Protein Refseq : NP_001089
MIM : 100850
UniProt ID : Q99798

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the function of ACO2? 12/29/2022

ACO2 is involved in the TCA cycle, which is a critical process for energy production in cells. Specifically, it catalyzes the conversion of citrate to isocitrate, which is a crucial step in the cycle.

Can ACO2 mutations cause disease? 12/11/2022

Yes, mutations in the ACO2 gene have been associated with several disorders, including infantile cerebellar-retinal degeneration and mitochondrial encephalopathy. These conditions are characterized by a range of symptoms, including neurological and developmental abnormalities.

Can ACO2 be targeted for medical treatment?  10/05/2021

ACO2 is a potential target for cancer treatment, as it is overexpressed in several types of cancer cells. However, the development of drugs that target ACO2 is still in the early stages of research.

How does ACO2 differ from ACO1? 04/28/2021

ACO1 and ACO2 are two isoforms of aconitate hydratase, which catalyze the same reaction in the TCA cycle. However, ACO2 is primarily located in the mitochondria of cells, while ACO1 is located in the cytoplasm.

Is ACO2 involved in iron metabolism? 10/30/2018

Unlike ACO1, ACO2 is not involved in iron metabolism. Its role is primarily in energy production through the TCA cycle.

What happens if ACO2 is deficient? 09/26/2018

ACO2 deficiency has been associated with several disorders, including infantile cerebellar-retinal degeneration and mitochondrial encephalopathy. These conditions are characterized by various neurological and developmental abnormalities.

What is the structure of ACO2? 06/23/2018

ACO2 is a homodimeric enzyme composed of two identical subunits. Each subunit contains a catalytic domain and a regulatory domain, which work together to catalyze the isomerization of citrate to isocitrate.

How is ACO2 measured in the laboratory?  10/02/2017

ACO2 activity can be measured in the laboratory using a variety of techniques, including spectrophotometric assays and enzymatic activity assays. These assays typically involve measuring the rate of citrate isomerization to isocitrate in the presence of ACO2 and other necessary cofactors.

How is the activity of ACO2 regulated? 09/29/2017

ACO2 activity is regulated by a variety of factors, including substrate availability, pH, and post-translational modifications such as phosphorylation. Additionally, ACO2 activity can be modulated by other enzymes and metabolic pathways in the cell.

Does ACO2 have any other functions in addition to energy production? 06/30/2015

While ACO2 is primarily known for its role in energy production, recent research suggests that it may also play a role in other cellular processes. For example, studies have shown that ACO2 may be involved in regulating the immune response and cellular metabolism.

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