Recombinant Human Activin ACVR1B protein, Fc-tagged
Cat.No. : | ACVR1B-332H |
Product Overview : | Recombinant Human ACVR1B protein (Ser24-Glu126), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Activin receptor type-1B (ACVR1B) is also known as Activin receptor-like kinase 4 (ALK-4), Serine/threonine-protein kinase receptor R2 (SKR2), which belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. ACVR1B contains one GS domain and one protein kinase domain. The catalytic activity of ACVR1B is "ATP + [receptor-protein] = ADP + [receptor-protein] phosphate". ACVR1B acts as a transducer of activin or activin like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. ACVR1B also transduces signals of nodal, GDF-1, and Vg1. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 38.1 kDa. As a result of glycosylation, the protein migrates as 43-46 kDa under reducing (R) condition, and 85-90 kDa under non-reducing (NR) condition (SDS-PAGE). |
Protein length : | 103 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >92% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | ACVR1B |
Official Symbol : | ACVR1B |
Synonyms : | ACVR1B; activin A receptor, type IB; ACVRLK4; activin receptor type-1B; ActRIB; ALK4; SKR2; activin receptor-like kinase 4; activin A receptor, type II-like kinase 4; serine/threonine-protein kinase receptor R2; ACTRIB |
Gene ID : | 91 |
mRNA Refseq : | NM_004302 |
Protein Refseq : | NP_004293 |
MIM : | 601300 |
UniProt ID : | P36896 |
Products Types
◆ Recombinant Protein | ||
ACVR1B-082H | Recombinant Human ACVR1B Protein, Fc-tagged | +Inquiry |
ACVR1B-59R | Recombinant Rhesus Macaque ACVR1B Protein, His (Fc)-Avi-tagged | +Inquiry |
ACVR1B-148R | Recombinant Rat ACVR1B Protein, His (Fc)-Avi-tagged | +Inquiry |
Acvr1b-288M | Recombinant Mouse Acvr1b Protein, His-tagged | +Inquiry |
Acvr1b-1M | Recombinant Mouse Acvr1b Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ACVR1B-2130HCL | Recombinant Human ACVR1B cell lysate | +Inquiry |
ACVR1B-1356CCL | Recombinant Cynomolgus ACVR1B cell lysate | +Inquiry |
ACVR1B-1206RCL | Recombinant Rat ACVR1B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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