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Recombinant Human AOC2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : AOC2-4669H
Product Overview : AOC2 MS Standard C13 and N15-labeled recombinant protein (NP_033720) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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  • Gene Information
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Description : Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 83.5 kDa
AA Sequence : MHLKIVLAFLALSLITIFALAYVLL TSPGGSSQPPHCPSVSHRAQPWPHP GQSQLFADLSREELTAVMRFLTQRL GPGLVDAAQAQPSDNCIFSVELQLP PKAAALAHLDRGSPPPAREALAIVL FGGQPQPNVSELVVGPLPHPSYMRD VTVERHGGPLPYHRRPVLRAEFTQM WRHLKEVELPKAPIFLSSTFNYNGS TLAAVHATPRGLRSGDRATWMALYH NISGVGLFLHPVGLELLLDHRALDP AHWTVQQVFYLGHYYADLGQLEREF KSGRLEVVRVPLPPPNGASSLRSRN SPGPLPPLQFSPQGSQYSVQGNLVV SSLWSFTFGHGVFSGLRIFDVRFQG ERIAYEVSVQECVSIYGADSPKTML TRYLDSSFGLGRNSRGLVRGVDCPY QATMVDIHILVGKGAVQLLPGAVCV FEEAQGLPLRRHHNYLQNHFYGGLA SSALVVRSVSSVGNYDYIWDFVLYP NGALEGRVHATGYINTAFLKGGEEG LLFGNRVGERVLGTVHTHAFHFKLD LDVAGLKNWVVAEDVVFKPVAAPWN PEHWLQRPQLTRQVLGKEDLTAFSL GSPLPRYLYLASNQTNAWGHQRGYR IQIHSPLGIHIPLESDMERALSWGR YQLVVTQRKEEESQSSSIYHQNDIW TPTVTFADFINNETLLGEDLVAWVT ASFLHIPHAEDIPNTVTLGNRVGFL LRPYNFFDEDPSIFSPGSVYFEKGQ DAGLCSINPVACLPDLAACVPDLPP FSYHGFTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : AOC2 amine oxidase copper containing 2 [ Homo sapiens (human) ]
Official Symbol : AOC2
Synonyms : AOC2; amine oxidase, copper containing 2 (retina-specific); retina-specific copper amine oxidase; DAO2; RAO; SSAO; semicarbazide-sensitive amine oxidase;
Gene ID : 314
mRNA Refseq : NM_009590
Protein Refseq : NP_033720
MIM : 602268
UniProt ID : O75106

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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What is the application prospect of AOC2 ? 11/22/2022

AOC2 has important application potential in many fields such as biological science and medical field, and has a very wide application prospect.

What are the potential effects of AOC2 in clinical diseases? 08/23/2022

AOC2 has potential therapeutic effects in the treatment of kidney disease and cancer.

How to apply AOC2 in tumor therapy? 05/30/2022

At present, the specific application of AOC2 in tumor therapy still needs to be further studied.

Does the clinical research results of AOC2 in the treatment of tumor? 05/22/2022

At present, the clinical study of AOC2 in the treatment of tumor has not been conclusive, and further research is needed.

How to adjust the dose of AOC2 ? 02/11/2022

The dose of AOC2 needs to be adjusted individually according to the clinical situation. In general, use strictly according to the doctor's advice.

Is the production technology of AOC2 mature? 01/07/2022

Yes, some mature production technologies have been developed and the corresponding processes have been applied on a large scale.

What are the properties of AOC2 ? 09/18/2021

AOC2 is a recombinant human protein from exons, and its structure and function conform to physiological characteristics.

Which the factors affecting human health of AOC2 ? 08/23/2021

AOC2 has been implicated in the occurrence and development of certain kidney diseases, as well as in the occurrence and development of tumors.

What are the similarities and differences between AOC2 and other biosimilar products? 05/18/2021

AOC2 has higher biological activity and stability compared with other similar biological products.

Is there a renewable source of AOC2 ? 02/27/2021

Yes, AOC2 can be mass-produced through cell culture, genetic engineering and other technologies.

Has AOC2 been approved by the national regulatory authority? 02/16/2021

It is necessary to go through the relevant approval process to obtain the approval of the national regulatory authority for use.

How to solve the technical problems encountered in the production process of AOC2 ? 07/24/2020

It is necessary to solve relevant technical problems by strengthening research and developing new process technologies.

What is the specific scope of use of AOC2 ? 01/20/2020

AOC2 is used in many fields such as kidney disease treatment and tumor treatment.

What are the clinical research results of AOC2 in the treatment of kidney disease? 08/18/2019

AOC2 can alleviate physiological processes such as renal fibrosis and inflammatory response, and has a potential role in the prevention and treatment of kidney diseases.

Does AOC2 have an impact on human reproductive health? 08/01/2019

No studies have shown that AOC2 has adverse effects on human reproductive health.

What is the action principle of AOC2 in the treatment of kidney diseases and tumors? 07/08/2019

The regulation of AOC2 on intracellular oxygen molecules is related to anti-oxidative stress, and can also affect cell cycle, proliferation and apoptosis.

Does the use of AOC2 require clinical trials? 05/17/2019

Yes, AOC2 needs to undergo relevant clinical trials to evaluate its efficacy and safety.

Are there side effects of AOC2 ? 02/07/2019

Recombinant AOC2 proteins may have some side effects, such as headache, nausea, pain, etc., but they are relatively rare.

Customer Reviews (3)

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Reviews
10/19/2022

    Immunogenicity of AOC2 is very weak, does not cause an immune response, and is very safe.

    06/12/2022

      The catalytic activity of AOC2 is very excellent, and it can be widely used in various chemical reactions, and has high practical value.

      02/12/2021

        Repeatability is very good, can reduce unnecessary repeated experiments, improve the efficiency of the experiment.

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