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Recombinant Human ARHGAP15 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : ARHGAP15-2999H
Product Overview : ARHGAP15 MS Standard C13 and N15-labeled recombinant protein (NP_060930) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : RHO GTPases regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 54.5 kDa
AA Sequence : MQKSTNSDTSVETLNSTRQGTGAVQ MRIKNANSHHDRLSQSKSMILTDVG KVTEPISRHRRNHSQHILKDVIPPL EQLMVEKEGYLQKAKIADGGKKLRK NWSTSWIVLSSRRIEFYKESKQQAL SNMKTGHKPESVDLCGAHIEWAKEK SSRKNVFQITTVSGNEFLLQSDIDF IILDWFHAIKNAIDRLPKDSSCPSR NLELFKIQRSSSTELLSHYDSDIKE QKPEHRKSLMFRLHHSASDTSDKNR VKSRLKKFITRRPSLKTLQEKGLIK DQIFGSHLHKVCERENSTVPWFVKQ CIEAVEKRGLDVDGIYRVSGNLATI QKLRFIVNQEEKLNLDDSQWEDIHV VTGALKMFFRELPEPLFPYSFFEQF VEAIKKQDNNTRIEAVKSLVQKLPP PNRDTMKVPFGHLTKIVAKASKNLM STQSLGIVFGPTLLRAENETGNMAI HMVYQNQIAELMLSEYSKIFGSEED TRTRPLEQKLISEEDLAANDILDYK DDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : ARHGAP15 Rho GTPase activating protein 15 [ Homo sapiens (human) ]
Official Symbol : ARHGAP15
Synonyms : ARHGAP15; Rho GTPase activating protein 15; rho GTPase-activating protein 15; BM046; rho-type GTPase-activating protein 15;
Gene ID : 55843
mRNA Refseq : NM_018460
Protein Refseq : NP_060930
MIM : 610578
UniProt ID : Q53QZ3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (17)

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How does ARHGAP15 regulate Rho GTPase activity? 09/17/2022

ARHGAP15 functions as a GTPase-activating protein (GAP), which means it enhances the intrinsic GTPase activity of Rho GTPases. By catalyzing the hydrolysis of GTP to GDP, ARHGAP15 promotes the inactivation of Rho GTPases, leading to changes in cellular processes.

Has ARHGAP15 been studied in cancer biology? 08/05/2022

Yes, ARHGAP15 has been investigated in cancer biology. Studies have shown that it can function as a tumor suppressor by inhibiting cell proliferation, promoting apoptosis, and suppressing tumor growth in various cancer types. Additionally, altered expression of ARHGAP15 has been observed in certain cancers. However, more research is required to fully understand the role of ARHGAP15 in cancer development and progression.

Can ARHGAP15 affect cell migration and cell adhesion? 08/10/2021

Yes, ARHGAP15 can influence cell migration and cell adhesion. Through its regulation of Rho GTPases, ARHGAP15 impacts the organization of the actin cytoskeleton, which is crucial for these cellular processes.

Are there any known protein interactors or binding partners of ARHGAP15? 03/04/2021

The protein interactors or binding partners of ARHGAP15 have not been extensively studied. Further research is necessary to identify and characterize potential protein interactors.

Are there any known cellular processes or pathways that ARHGAP15 is involved in? 01/18/2021

ARHGAP15 is implicated in various cellular processes and signaling pathways, including cytoskeletal dynamics, cell migration, cell adhesion, and cell polarity. It interacts with Rho GTPases to modulate these processes, contributing to cellular homeostasis and tissue development.

Is ARHGAP15 or its expression altered in any disease conditions? 01/24/2020

Currently, specific alterations in ARHGAP15 expression or function in disease conditions have not been well-established. However, given its role in cellular processes, dysregulation of ARHGAP15 could potentially contribute to various diseases. Further research is necessary to elucidate any disease-associated changes.

Is ARHGAP15 linked to cancer progression or metastasis? 01/03/2020

As Rho GTPases are frequently dysregulated in cancer and play critical roles in tumor progression and metastasis, it is possible that ARHGAP15, as a regulator of Rho GTPases, could indirectly influence cancer-related processes. However, more research is needed to establish any direct links between ARHGAP15 and cancer progression or metastasis.

Is ARHGAP15 essential for embryonic development? 11/23/2019

The essentiality of ARHGAP15 during embryonic development has not been extensively studied. However, as Rho GTPases have critical roles in embryogenesis, it is possible that ARHGAP15 may play a role in this context. Further research is needed to determine its specific contribution to embryonic development.

Are there any animal models available to study ARHGAP15 function? 07/12/2019

Animal models specifically targeting ARHGAP15 have not been reported extensively. However, some studies have utilized cellular models and knockout mice to investigate the role of ARHGAP15 in cellular processes. The development of animal models would be valuable for elucidating its physiological significance.

Are there any known ARHGAP15 polymorphisms that are associated with phenotypic variations in humans? 01/15/2019

There is limited information regarding ARHGAP15 polymorphisms associated with phenotypic variations in humans. The genetic variations or single nucleotide polymorphisms (SNPs) within ARHGAP15 and their association with specific traits, diseases, or phenotypic variations have not been well-studied. Further investigation is needed to understand the impact of ARHGAP15 polymorphisms on human phenotypes.

Is ARHGAP15 involved in neurite outgrowth or neuronal development? 12/21/2018

The specific role of ARHGAP15 in neurite outgrowth or neuronal development is currently unclear. However, as Rho GTPases are involved in regulating neuronal processes, it is plausible that ARHGAP15 may have an impact on these cellular events.

Which Rho GTPases does ARHGAP15 interact with? 07/04/2018

ARHGAP15 interacts with RhoA, RhoB, and Rac1, which are members of the Rho family of GTPases. These interactions enable ARHGAP15 to regulate the signaling pathways involving these GTPases.

Does ARHGAP15 have any known protein domains or motifs? 06/05/2018

ARHGAP15 contains a Rho GTPase-activating protein (GAP) domain, which is responsible for its interaction with and modulation of Rho GTPases. This domain enables ARHGAP15 to catalyze GTP hydrolysis and regulate the activity of Rho GTPases.

Are there any studies on the role of ARHGAP15 in immune function or inflammation? 05/16/2018

Currently, there are limited studies exploring the role of ARHGAP15 in immune function or inflammation. However, since Rho GTPases play crucial roles in immune cell activation, migration, and inflammatory responses, it is plausible that ARHGAP15 could impact these processes. Further research is needed to elucidate the involvement of ARHGAP15 in immune function and inflammation.

Are there any known diseases or disorders associated with ARHGAP15? 12/05/2017

Currently, there are no reported diseases or disorders specifically linked to mutations or dysregulation of ARHGAP15. However, further studies may provide insights into any potential associations with specific conditions.

Can ARHGAP15 interact with other cellular proteins or signaling molecules? 10/02/2016

ARHGAP15 may interact with other cellular proteins or signaling molecules to modulate its function and downstream signaling. However, the specific protein-protein interactions associated with ARHGAP15 have not been extensively characterized and require further investigation.

Does ARHGAP15 have any known regulatory mechanisms? 02/04/2016

Currently, there is limited understanding of the specific regulatory mechanisms governing ARHGAP15. However, factors like transcriptional regulation, post-translational modifications, and protein-protein interactions may play a role in modulating its expression, activity, and cellular localization.

Customer Reviews (8)

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Reviews
04/04/2023

    The ARHGAP15 protein surpasses expectations in terms of quality and is an ideal match for my experimental requirements.

    02/25/2022

      Their team of experts has been instrumental in resolving any queries or challenges I encountered regarding the application and utilization of the ARHGAP15 protein.

      10/24/2020

        the manufacturer can assist in sourcing complementary reagents and tools, such as specific antibodies or detection systems, to complement the use of ARHGAP15 protein in trials.

        09/27/2020

          manufacturers often have a wealth of knowledge and expertise in the field of ARHGAP15 protein research.

          08/07/2020

            Its impeccable purity and integrity make it a valuable asset in my research endeavors.

            12/09/2019

              Collaborative discussions with the manufacturer can also help optimize experimental protocols and provide insights into the best practices in working with ARHGAP15.

              07/01/2016

                I am profoundly impressed by the technical support rendered by the manufacturer.

                01/02/2016

                  They can offer specialized formulations, concentrations, or modifications of ARHGAP15 protein to suit unique experimental requirements.

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