| Description : |
This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
76.6 kDa |
| AA Sequence : |
MLSPKIRQARRARSKSLVMGEQSRS PGRMPCPHRLGPVLKAGWLKKQRSI MKNWQQRWFVLRGDQLFYYKDKDEI KPQGFISLQGTQVTELPPGPEDPGK HLFEISPGGAGEREKVPANPEALLL MASSQRDMEDWVQAIRRVIWAPLGG GIFGQRLEETVHHERKYGPRLAPLL VEQCVDFIRERGLTEEGLFRMPGQA NLVRDLQDSFDCGEKPLFDSTTDVH TVASLLKLYLRELPEPVVPFARYED FLSCAQLLTKDEGEGTLELAKQVSN LPQANYNLLRYICKFLDEVQAYSNV NKMSVQNLATVFGPNILRPQVEDPV TIMEGTSLVQHLMTVLIRKHSQLFT APVPEGPTSPRGGLQCAVGWGSEEV TRDSQGEPGGPGLPAHRTSSLDGAA VAVLSRTAPTGPGSRCSPGKKVQTL PSWKSSFRQPRSLSGSPKGGGSSLE VPIISSGGNWLMNGLSSLRGHRRAS SGDRLKDSGSVQRLSTYDNVPAPGL VPGIPSVASMAWSGASSSESSVGGS LSSCTACRASDSSARSSLHTDWALE PSPLPSSSEDPKSLDLDHSMDEAGA GASNSEPSEPDSPTREHARRSEALQ GLVTELRAELCRQRTEYERSVKRIE EGSADLRKRMSRLEEELDQEKKKYI MLEIKLRNSERAREDAERRNQLLQR EMEEFFSTLGSLTVGAKGARAPKTR TRPLEQKLISEEDLAANDILDYKDD DDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
