Active Recombinant Human ARTN Protein
Cat.No. : | ARTN-006H |
Product Overview : | The mature recombinant human GDNF protein consists of 118 amino acids (108-220) without tag was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. |
Source : | E. coli |
Species : | Human |
Bio-activity : | Measured in a cell proliferation assay using SH-SY5Y human neuroblastoma cells. The ED50 for this effect is 4-16 ng/mL. Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human GFR alpha -3/GDNF R alpha -3 Fc Chimera at 1 μg/mL (100 μL/well) can bind Recombinant Human Artemin with an apparent Kd <1 nM. |
Molecular Mass : | 24.2 kDa |
Product-Related Proteins : | 108-220 |
Endotoxin : | < 0.1 EU/μg of the protein as determined by the LAL method |
Purity : | > 95 % as determined by SDS-PAGE |
Storage : | At -80 centigrade. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | PBS |
Gene Name : | ARTN artemin [ Homo sapiens (human) ] |
Official Symbol : | ARTN |
Synonyms : | ARTN; artemin; ART; EVN; NBN; ENOVIN; artemin; neublastin |
Gene ID : | 9048 |
mRNA Refseq : | NM_057091 |
Protein Refseq : | NP_476432 |
MIM : | 603886 |
UniProt ID : | Q5T4W7 |
Products Types
◆ Recombinant Protein | ||
ARTN-467R | Recombinant Rat ARTN Protein, His (Fc)-Avi-tagged | +Inquiry |
ARTN-03H | Recombinant Human ARTN Protein | +Inquiry |
ARTN-703H | Recombinant Human ARTN Protein | +Inquiry |
ARTN-12H | Recombinant Human Artemin | +Inquiry |
ARTN-801H | Active Recombinant Human ARTN | +Inquiry |
◆ Lysates | ||
ARTN-134HCL | Recombinant Human ARTN cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (8)
Ask a questionThe ARTN protein activates various signaling pathways, including the RET receptor tyrosine kinase pathway and the AKT and MAPK/ERK pathways, to mediate its neurotrophic effects.
Yes, the ARTN protein has neuroprotective effects and can promote the survival of neurons under conditions of stress or injury, such as oxidative stress or neuronal damage.
Dysregulation of the ARTN protein has been implicated in neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Further research is needed to understand the underlying mechanisms.
Yes, the ARTN protein is involved in the development of the nervous system. It plays a role in guiding growing axons and promoting the survival and differentiation of neurons during development.
The potential therapeutic use of the ARTN protein is being explored, particularly for neurodegenerative diseases, but further research is needed to evaluate its effectiveness and safety.
Yes, the ARTN protein has immunomodulatory properties. It can influence immune cell activity and promote anti-inflammatory responses in certain contexts.
As of now, no specific mutations in the ARTN gene linked to neurological disorders have been reported. However, ongoing genomic studies might uncover any potential disease associations.
Yes, the ARTN protein has been implicated in pain perception. It has been shown to influence the sensitivity of sensory neurons and modulate pain signaling pathways.
Customer Reviews (3)
Write a reviewI highly endorse the utilization of the ARTN Protein for researchers seeking a superior protein solution that not only meets their experimental needs but also benefits from the exceptional technical support provided by the manufacturer.
Their team of experts has been extremely helpful in addressing any concerns or queries I encountered during my experiments.
Its exceptional purity and consistency have consistently yielded reliable and reproducible results, ensuring the accuracy and reliability of my research outcomes.
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