| Description : |
This gene encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. Processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid. This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene are associated with the lysosomal storage disorder, Farber lipogranulomatosis, and a neuromuscular disorder, spinal muscular atrophy with progressive myoclonic epilepsy. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
46.3 kDa |
| AA Sequence : |
MNCCIGLGEKARGSHRASYPSLSAL FTEASILGFGSFAVKAQWTEDCRKS TYPPSGPTYRGAVPWYTINLDLPPY KRWHELMLDKAPMLKVIVNSLKNMI NTFVPSGKVMQVVDEKLPGLLGNFP GPFEEEMKGIAAVTDIPLGEIISFN IFYELFTICTSIVAEDKKGHLIHGR NMDFGVFLGWNINNDTWVITEQLKP LTVNLDFQRNNKTVFKASSFAGYVG MLTGFKPGLFSLTLNERFSINGGYL GILEWILGKKDAMWIGFLTRTVLEN STSYEEAKNLLTKTKILAPAYFILG GNQSGEGCVITRDRKESLDVYELDA KQGRWYVVQTNYDRWKHPFFLDDRR TPAKMCLNRTSQENISFETMYDVLS TKPVLNKLTVYTTLIDVTKGQFETY LRDCPDPCIGWTRTRPLEQKLISEE DLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
