| Description : |
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
133.8 kDa |
| AA Sequence : |
MTNPSDRVLPANSMAESREGDFGCT VMELRKLMELRSRDALTQINVHYGG VQNLCSRLKTSPVEGLSGNPADLEK RRQVFGHNVIPPKKPKTFLELVWEA LQDVTLIILEIAAIISLVLSFYRPA GEENELCGQVATTPEDENEAQAGWI EGAAILFSVIIVVLVTAFNDWSKEK QFRGLQCRIEQEQKFSIIRNGQLIQ LPVAEIVVGDIAQVKYGDLLPADGI LIQGNDLKIDESSLTGESDHVKKSL DKDPMLLSGTHVMEGSGRMVVTAVG VNSQTGIILTLLGVNEDDEGEKKKK GKKQGVPENRNKAKTQDGVALEIQP LNSQEGIDNEEKDKKAVKVPKKEKS VLQGKLTRLAVQIGKAGLLMSALTV FILILYFVIDNFVINRRPWLPECTP IYIQYFVKFFIIGITVLVVAVPEGL PLAVTISLAYSVKKMMKDNNLVRHL DACETMGNATAICSDKTGTLTMNRM TVVQAYIGGIHYRQIPSPDVFLPKV LDLIVNGISINSAYTSKILPPEKEG GLPRQVGNKTECALLGFVTDLKQDY QAVRNEVPEEKLYKVYTFNSVRKSM STVIRNPNGGFRMYSKGASEIILRK CNRILDRKGEAVPFKNKDRDDMVRT VIEPMACDGLRTICIAYRDFDDTEP SWDNENEILTELTCIAVVGIEDPVR PEVPDAIAKCKQAGITVRMVTGDNI NTARAIATKCGILTPGDDFLCLEGK EFNRLIRNEKGEVEQEKLDKIWPKL RVLARSSPTDKHTLVKGIIDSTVGE HRQVVAVTGDGTNDGPALKKADVGF AMGIAGTDVAKEASDIILTDDNFTS IVKAVMWGRNVYDSISKFLQFQLTV NVVAVIVAFTGACITQDSPLKAVQM LWVNLIMDTFASLALATEPPTESLL KRRPYGRNKPLISRTMMKNILGHAF YQLIVIFILVFAGEKFFDIDSGRKA PLHSPPSQHYTIVFNTFVLMQLFNE INSRKIHGEKNVFSGIYRNIIFCSV VLGTFICQIFIVEFGGKPFSCTSLS LSQWLWCLFIGIGELLWGQFISAIP TRSLKFLKEAGHGTTKEEITKDAEG LDEIDHAEMELRRGQILWFRGLNRI QTQIKVVKAFHSSLHESIQKPYNQK SIHSFMTHPEFAIEEELPRTPLLDE EEEENPDKASKFGTRVLLLDGEVTP YANTNNNAVDCNQVQLPQSDSSLQS LETSVTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
