Recombinant Human ATXN10 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: ATXN10-3556H
• Product Overview: ATXN10 MS Standard C13 and N15-labeled recombinant protein (NP_037368) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 53.5 kDa
• AA Sequence: MAAPRPPPARLSGVMVPAPIQDLEA LRALTALFKEQRNRETAPRTIFQRV LDILKKSSHAVELACRDPSQVENLA SSLQLITECFRCLRNACIECSVNQN SIRNLDTIGVAVDLILLFRELRVEQ ESLLTAFRCGLQFLGNIASRNEDSQ SIVWVHAFPELFLSCLNHPDKKIVA YSSMILFTSLNHERMKELEENLNIA IDVIDAYQKHPESEWPFLIITDLFL KSPELVQAMFPKLNNQERVTLLDLM IAKITSDEPLTKDDIPVFLRHAELI ASTFVDQCKTVLKLASEEPPDDEEA LATIRLLDVLCEMTVNTELLGYLQV FPGLLERVIDLLRVIHVAGKETTNI FSNCGCVRAEGDISNVANGFKSHLI RLIGNLCYKNKDNQDKVNELDGIPL ILDNCNISDSNPFLTQWVIYAIRNL TEDNSQNQDLIAKMEEQGLADASLL KKVGFEVEKKGEKLILKSTRDTPKP TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: ATXN10 ataxin 10 [ Homo sapiens (human) ]
• Official Symbol: ATXN10
• Synonyms: ATXN10; ataxin 10; SCA10, spinocerebellar ataxia 10; ataxin-10; E46L; FLJ37990; brain protein E46 homolog; spinocerebellar ataxia type 10 protein; SCA10; HUMEEP
• Gene ID: 25814
• mRNA Refseq: NM_013236
• Protein Refseq: NP_037368
• MIM: 611150
• UniProt ID: Q9UBB4