Recombinant Human BACE1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: BACE1-2682H
• Product Overview: BACE1 MS Standard C13 and N15-labeled recombinant protein (NP_036236) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 55.8 kDa
• AA Sequence: MAQALPWLLLWMGAGVLPAHGTQHG IRLPLRSGLGGAPLGLRLPRETDEE PEEPGRRGSFVEMVDNLRGKSGQGY YVEMTVGSPPQTLNILVDTGSSNFA VGAAPHPFLHRYYQRQLSSTYRDLR KGVYVPYTQGKWEGELGTDLVSIPH GPNVTVRANIAAITESDKFFINGSN WEGILGLAYAEIARPDDSLEPFFDS LVKQTHVPNLFSLQLCGAGFPLNQS EVLASVGGSMIIGGIDHSLYTGSLW YTPIRREWYYEVIIVRVEINGQDLK MDCKEYNYDKSIVDSGTTNLRLPKK VFEAAVKSIKAASSTEKFPDGFWLG EQLVCWQAGTTPWNIFPVISLYLMG EVTNQSFRITILPQQYLRPVEDVAT SQDDCYKFAISQSSTGTVMGAVIME GFYVVFDRARKRIGFAVSACHVHDE FRTAAVEGPFVTLDMEDCGYNIPQT DESTLMTIAYVMAAICALFMLPLCL MVCQWRCLRCLRQQHDDFADDISLL KTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: BACE1 beta-site APP-cleaving enzyme 1 [ Homo sapiens (human) ]
• Official Symbol: BACE1
• Synonyms: BACE1; beta-site APP-cleaving enzyme 1; BACE, beta site APP cleaving enzyme; beta-secretase 1; asp 2; memapsin-2; APP beta-secretase; aspartyl protease 2; beta-site APP cleaving enzyme 1; beta-secretase 1 precursor variant 1; transmembrane aspartic proteinase Asp2; membrane-associated aspartic protease 2; beta-site amyloid beta A4 precursor protein-cleaving enzyme; ASP2; BACE; HSPC104; FLJ90568; KIAA1149
• Gene ID: 23621
• mRNA Refseq: NM_012104
• Protein Refseq: NP_036236
• MIM: 604252
• UniProt ID: P56817