Recombinant Human BCL2L12 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: BCL2L12-2821H
• Product Overview: BCL2L12 MS Standard C13 and N15-labeled recombinant protein (NP_619580) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 36.6 kDa
• AA Sequence: MGRPAGLFPPLCPFLGFRPEACWER HMQIERAPSVPPFLRWAGYRPGPVR RRGKVELIKFVRVQWRRPQVEWRRR RWGPGPGASMAGSEELGLREDTLRV LAAFLRRGEAAGSPVPTPPRSPAQE EPTDFLSRLRRCLPCSLGRGAAPSE SPRPCSLPIRPCYGLEPGPATPDFY ALVAQRLEQLVQEQLKSPPSPELQG PPSTEKEAILRRLVALLEEEAEVIN QKLASDPALRSKLVRLSSDSFARLV ELFCSRDDSSRPSRACPGPPPPSPE PLARLALAMELSRRVAGLGGTLAGL SVEHVHSFTPWIQAHGGWEGILAVS PVDLNLPLDTRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: BCL2L12 BCL2 like 12 [ Homo sapiens (human) ]
• Official Symbol: BCL2L12
• Synonyms: BCL2L12; BCL2-like 12 (proline rich); bcl-2-like protein 12; bcl2-L-12; Bcl-2 related proline-rich protein; bcl-2-related proline-rich protein; MGC120313; MGC120314; MGC120315
• Gene ID: 83596
• mRNA Refseq: NM_138639
• Protein Refseq: NP_619580
• MIM: 610837
• UniProt ID: Q9HB09