| Description : |
This gene encodes an adaptor protein that belongs to the bicaudal D family of dynein cargo adaptors. The encoded protein acts as an intracellular cargo transport cofactor that regulates the microtubule-based loading of cargo onto the dynein motor complex. It also controls dynein motor activity and coordination. It has a domain architecture consisting of coiled-coil domains at the N- and C-termini that are highly conserved in other family members. Naturally occurring mutations in this gene are associated with short telomere length and emphysema. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
110.6 kDa |
| AA Sequence : |
MAAEEVLQTVDHYKTEIERLTKELT ETTHEKIQAAEYGLVVLEEKLTLKQ QYDELEAEYDSLKQELEQLKEAFGQ SFSIHRKVAEDGETREETLLQESAS KEAYYLGKILEMQNELKQSRAVVTN VQAENERLTAVVQDLKENNEMVELQ RIRMKDEIREYKFREARLLQDYTEL EEENITLQKLVSTLKQNQVEYEGLK HEIKRFEEETVLLNSQLEDAIRLKE IAEHQLEEALETLKNEREQKNNLRK ELSQYISLNDNHISISVDGLKFAED GSEPNNDDKMNGHIHGPLVKLNGDY RTPTLRKGESLNPVSDLFSELNISE IQKLKQQLMQVEREKAILLANLQES QTQLEHTKGALTEQHERVHRLTEHV NAMRGLQSSKELKAELDGEKGRDSG EEAHDYEVDINGLEILECKYRVAVT EVIDLKAEIKALKEKYNKSVENYTD EKAKYESKIQMYDEQVTSLEKTTKE SGEKMAHMEKELQKMTSIANENHST LNTAQDELVTFSEELAQLYHHVCLC NNETPNRVMLDYYRQSRVTRSGSLK GPDDPRGLLSPRLARRGVSSPVETR TSSEPVAKESTEASKEPSPTKTPTI SPVITAPPSSPVLDTSDIRKEPMNI YNLNAIIRDQIKHLQKAVDRSLQLS RQRAAARELAPMIDKDKEALMEEIL KLKSLLSTKREQIATLRAVLKANKQ TAEVALANLKNKYENEKAMVTETMT KLRNELKALKEDAATFSSLRAMFAT RCDEYVTQLDEMQRQLAAAEDEKKT LNTLLRMAIQQKLALTQRLEDLEFD HEQSRRSKGKLGKSKIGSPKVSGEA SVTVPTIDTYLLHSQGPQTPNIRVS SGTQRKRQFSPSLCDQSRPRTSGAS YLQNLLRVPPDPTSTESFLLKGPPS MSEFIQGHRLSKEKRLTVAPPDCQQ PAASVPPQCSQLAGRQDCPTVSPDT ALPEEQPHSSSQCAPLHCLSKPPHP TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
