| Description : |
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. |
| Source : |
E. coli |
| Species : |
Human |
| Bio-activity : |
Measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.02-0.15 μg/mL. |
| Molecular Mass : |
15 kDa |
| Product-Related Proteins : |
382-513 |
| Endotoxin : |
< 0.1 EU/μg of the protein as determined by the LAL method |
| Purity : |
> 95 % as determined by SDS-PAGE |
| Storage : |
At -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : |
PBS |
