Active Recombinant Human BMPR1B Protein, Fc Chimera

• Cat.No.: BMPR1B-889H
• Product Overview: Recombinant Human BMPR1B (Accession # O00238), fused with , was produced in Mouse myeloma cell line, NS0-derived.

Specification

• Source: Mammalian cells
• Species: Human
• Tag: Fc
• Predicted N Terminal: Met
• Form: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit rhBMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351.The ED50 for this effect is typically 0.5 - 1.5 µg/mL in the presence of 30 ng/mL of rhBMP-4.
• Molecular Mass: Recombinant Human BMPR1B, Fc Chimera has a calculated MW of 40 kDa (monomer). In SDS-PAGE migrates as 50-55 kDa, reducing conditions.
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).

Gene Information

• Gene Name: BMPR1B bone morphogenetic protein receptor, type IB [ Homo sapiens ]
• Official Symbol: BMPR1B
• Synonyms: BMPR1B; bone morphogenetic protein receptor, type IB; bone morphogenetic protein receptor type-1B; ALK6; CDw293; BMPR-1B; BMP type-1B receptor; activin receptor-like kinase 6; serine/threonine receptor kinase; ALK-6
• Gene ID: 658
• mRNA Refseq: NM_001203
• Protein Refseq: NP_001194
• MIM: 603248
• UniProt ID: O00238
• Chromosome Location: 4q23-q24