| Description : |
The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in this gene are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in this gene are associated with osteoporosis, and overexpression of this gene in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
33 kDa |
| AA Sequence : |
MADLSFIEDTVAFPEKEEDEEEEEE GVEWGYEEGVEWGLVFPDANGEYQS PINLNSREARYDPSLLDVRLSPNYV VCRDCEVTNDGHTIQVILKSKSVLS GGPLPQGHEFELYEVRFHWGRENQR GSEHTVNFKAFPMELHLIHWNSTLF GSIDEAVGKPHGIAIIALFVQIGKE HVGLKAVTEILQDIQYKGKSKTIPC FNPNTLLPDPLLRDYWVYEGSLTIP PCSEGVTWILFRYPLTISQLQIEEF RRLRTHVKGAELVEGCDGILGDNFR PTQPLSDRVIRAAFQTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
