Recombinant Human CALR Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CALR-2764H
• Product Overview: CALR MS Standard C13 and N15-labeled recombinant protein (NP_004334) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 48.1 kDa
• AA Sequence: MLLSVPLLLGLLGLAVAEPAVYFKE QFLDGDGWTSRWIESKHKSDFGKFV LSSGKFYGDEEKDKGLQTSQDARFY ALSASFEPFSNKGQTLVVQFTVKHE QNIDCGGGYVKLFPNSLDQTDMHGD SEYNIMFGPDICGPGTKKVHVIFNY KGKNVLINKDIRCKDDEFTHLYTLI VRPDNTYEVKIDNSQVESGSLEDDW DFLPPKKIKDPDASKPEDWDERAKI DDPTDSKPEDWDKPEHIPDPDAKKP EDWDEEMDGEWEPPVIQNPEYKGEW KPRQIDNPDYKGTWIHPEIDNPEYS PDPSIYAYDNFGVLGLDLWQVKSGT IFDNFLITNDEAYAEEFGNETWGVT KAAEKQMKDKQDEEQRLKEEEEDKK RKEEEEAEDKEDDEDKDEDEEDEED KEEDEEEDVPGQAKDELTRTRPLEQ KLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CALR calreticulin [ Homo sapiens (human) ]
• Official Symbol: CALR
• Synonyms: CALR; calreticulin; autoantigen Ro; cC1qR; CRT; FLJ26680; RO; Sicca syndrome antigen A (autoantigen Ro; calreticulin); SSA; CRP55; ERp60; HACBP; grp60; calregulin; endoplasmic reticulum resident protein 60; Sicca syndrome antigen A (autoantigen Ro; calreticulin)
• Gene ID: 811
• mRNA Refseq: NM_004343
• Protein Refseq: NP_004334
• MIM: 109091
• UniProt ID: P27797