| Description : |
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
133.3 kDa |
| AA Sequence : |
Tag(s)MPGGGPEMDDYMETLKDEEDALWEN VECNRHMLSRYINPAKLTPYLRQCK VIDEQDEDEVLNAPMLPSKINRAGR LLDILHTKGQRGYVVFLESLEFYYP ELYKLVTGKEPTRRFSTIVVEEGHE GLTHFLMNEVIKLQQQMKAKDLQRC ELLARLRQLEDEKKQMTLTRVELLT FQERYYKMKEERDSYNDELVKVKDD NYNLAMRYAQLSEEKNMAVMRSRDL QLEIDQLKHRLNKMEEECKLERNQS LKLKNDIENRPKKEQVLELERENEM LKTKNQELQSIIQAGKRSLPDSDKA ILDILEHDRKEALEDRQELVNRIYN LQEEARQAEELRDKYLEEKEDLELK CSTLGKDCEMYKHRMNTVMLQLEEV ERERDQAFHSRDEAQTQYSQCLIEK DKYRKQIRELEEKNDEMRIEMVRRE ACIVNLESKLRRLSKDSNNLDQSLP RNLPVTIISQDFGDASPRTNGQEAD DSSTSEESPEDSKYFLPYHPPQRRM NLKGIQLQRAKSPISLKRTSDFQAK GHEEEGTDASPSSCGSLPITNSFTK MQPPRSRSSIMSITAEPPGNDSIVR RYKEDAPHRSTVEEDNDSGGFDALD LDDDSHERYSFGPSSIHSSSSSHQS EGLDAYDLEQVNLMFRKFSLERPFR PSVTSVGHVRGPGPSVQHTTLNGDS LTSQLTLLGGNARGSFVHSVKPGSL AEKAGLREGHQLLLLEGCIRGERQS VPLDTCTKEEAHWTIQRCSGPVTLH YKVNHEGYRKLVKDMEDGLITSGDS FYIRLNLNISSQLDACTMSLKCDDV VHVRDTMYQDRHEWLCARVDPFTDH DLDMGTIPSYSRAQQLLLVKLQRLM HRGSREEVDGTHHTLRALRNTLQPE EALSTSDPRVSPRLSRASFLFGQLL QFVSRSENKYKRMNSNERVRIISGS PLGSLARSSLDATKLLTEKQEELDP ESELGKNLSLIPYSLVRAFYCERRR PVLFTPTVLAKTLVQRLLNSGGAME FTICKSDIVTRDEFLRRQKTETIIY SREKNPNAFECIAPANIEAVAAKNK HCLLEAGIGCTRDLIKSNIYPIVLF IRVCEKNIKRFRKLLPRPETEEEFL RVCRLKEKELEALPCLYATVEPDMW GSVEELLRVVKDKIGEEQRKTIWVD EDQLSGPTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
