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Active Recombinant Human CCL20

Cat.No. : CCL20-296H
Product Overview : Recombinant human MIP-3α is a non-glycosylated protein, containing 70 amino acids and a molecular weight of 8.0 kDa.
  • Specification
  • Gene Information
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Description : Macrophage Inflammatory Protein-3 alpha (MIP-3α), also called CCL20, is expressed in the liver, lungs, lymph nodes and peripheral blood lymphocytes. MIP-3α is strongly up regulated by inflammatory signals, and down regulated by the antiinflammatory cytokine IL-10. MIP-3α signals through the G protein-coupled receptor, CCR6, and acts as a chemoattractant to lymphocytes and dendritic cells.
Source : E.coli
Species : Human
Appearance : Sterile filtered white lyophilized (freeze-dried) powder.
Form : Recombinant human MIP-3α is lyophilized with no additives.
Bio-activity : The activity is determined by its ability to act as a chemoattractant to human T cells and is typically in the range of 7 - 70 ng/mL.
Molecular Mass : 8.0 kDa
AA Sequence : ASNFDCCLGY TDRILHPKFI VGFTRQLANE GCDINAIIFH TKKKLSVCAN PKQTWVKYIV RLLSKKVKNM
Endotoxin : Measured by kinetic LAL analysis and is typically ≤ 1 EU/μg protein.
Purity : ≥ 97%
Stability : Lyophilized product is very stable at -20°C. Reconstituted material should be aliquoted and frozen at -20°C. It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage.
Reconstitution : Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/mL, which can be further diluted into other aqueous solutions.
Gene Name : CCL20 chemokine (C-C motif) ligand 20 [ Homo sapiens (human) ]
Official Symbol : CCL20
Synonyms : CCL20; CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; MIP-3-alpha; C-C motif chemokine 20; chemokine (C-C motif) ligand 20; CC chemokine LARC; beta chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20
Gene ID : 6364
mRNA Refseq : NM_004591
Protein Refseq : NP_004582
MIM : 601960
UniProt ID : P78556
Chromosome Location : 2q36.3
Pathway : Chemokine receptors bind chemokines; Chemokine signaling pathway; Class A/1 (Rhodopsin-like receptors)
Function : chemokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which CCL20 modulates the migration and differentiation of dendritic cells? 08/25/2022

CCL20 influences dendritic cell migration and differentiation, crucial for initiating immune responses.

How does CCL20 contribute to tumor progression and the formation of the tumor microenvironment in cancer? 07/07/2022

CCL20 contributes to cancer progression by shaping the tumor microenvironment and aiding tumor cell invasion.

What role does CCL20 play in the pathogenesis of autoimmune diseases like rheumatoid arthritis? 05/17/2022

CCL20 plays a significant role in autoimmune diseases by attracting inflammatory cells to affected joints.

How does CCL20 influence wound healing and tissue repair processes? 12/21/2021

CCL20 is involved in wound healing and tissue repair, facilitating immune cell migration and tissue regeneration.

How do alterations in CCL20 expression or signaling affect skin homeostasis and the development of skin diseases? 09/05/2021

Changes in CCL20 expression impact skin health, potentially contributing to the development of skin disorders.

How does CCL20 mediate the recruitment and activation of immune cells, particularly in inflammatory conditions? 08/22/2020

CCL20 recruits and activates immune cells to sites of inflammation, coordinating the immune response.

What is the impact of CCL20 on mucosal immunity, especially in the gut and respiratory tract? 08/06/2019

CCL20 impacts mucosal immunity, playing a critical role in immune defense in the gut and respiratory system.

Customer Reviews (3)

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Reviews
08/25/2020

    Expert protein engineering support, essential for our projects' progress.

    05/14/2020

      Consistent western blot results, an indispensable tool in our lab.

      08/22/2019

        Dependable protein quantification, ensures data precision in our work.

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