Active Recombinant Human CCL23 Protein

• Cat.No.: CCL23-034H
• Product Overview: Purified recombinant protein of Human chemokine (C-C motif) ligand 23 (CCL23 / MPIF-1)(Arg46-Asn120), transcript variant CKbeta8, was expressed in E. coli.

Specification

• Description: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013].
• Source: E. coli
• Species: Human
• Bio-activity: Bioactivity was measured by its property to chemoattract THP-1 cells in a dose dependent manner.
• Molecular Mass: 8.5 kDa
• Endotoxin: Less than 0.01 ng per µg protein as determined by the LAL method.
• Purity: > 98% as determined by Coomassie stained SDS-PAGE.
• Concentration: Protein formulated and vialed at >50 µg/mL in specified buffer
• Storage Buffer: 1 x PBS

Gene Information

• Gene Name: CCL23 chemokine (C-C motif) ligand 23 [ Homo sapiens ]
• Official Symbol: CCL23
• Synonyms: CCL23; chemokine (C-C motif) ligand 23; SCYA23, small inducible cytokine subfamily A (Cys Cys), member 23; C-C motif chemokine 23; Ckb 8; CKb8; MIP 3; MPIF 1; hmrp-2a; C6 beta-chemokine; small-inducible cytokine A23; macrophage inflammatory protein 3; myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; CK-BETA-8
• Gene ID: 6368
• mRNA Refseq: NM_005064
• Protein Refseq: NP_005055
• MIM: 602494
• UniProt ID: P55773