Active Recombinant Human CCL5 protein
Cat.No. : | CCL5-81H |
Product Overview : | Recombinant Human CCL5 was expressed in HEK293. |
- Specification
- Gene Information
- Related Products
Description : | Chemokine (C-C motif) ligand 5(CCL5), also known as RANTES (Regulated upon activation, Normal T cell Expressed and presumable Secreted) is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. RANTES is chemotactic for T cells, eosinophils, and basophils, and plays an active role in recruiting leukocytes in inflammatory sites. With the help of specific cytokines (i.e., IL-2 and IFN-γ) that are released by T cells, RANTES induces the proliferation and activation of certain natural-killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. RANTES is also an HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans. It has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). |
Source : | HEK293 |
Species : | Human |
Form : | Lyophilized after extensive dialysis against PBS. |
Bio-activity : | The EC50 value of human RANTES/CCL5 on Ca2+ mobilization assay in CHO-K1/Gα15/hCCR1 cells (human Gα15 and human CCR1 stably expressed in CHO-K1 cells) is less than 0.2 μg/ml. |
Molecular Mass : | 8 kDa, observed by reducing SDS-PAGE. |
Protein length : | 68 amino acids |
AA Sequence : | SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 98% as analyzed by SDS-PAGE. |
Storage : | Lyophilized recombinant human RANTES/CCL5 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, human RANTES/CCL5 should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade |
Reconstitution : | Reconstituted in ddH2O or PBS at 100 μg/ml. |
Gene Name : | CCL5 chemokine (C-C motif) ligand 5 [ Homo sapiens ] |
Official Symbol : | CCL5 |
Synonyms : | CCL5; chemokine (C-C motif) ligand 5; D17S136E, SCYA5, small inducible cytokine A5 (RANTES); C-C motif chemokine 5; beta chemokine RANTES; MGC17164; RANTES; regulated upon activation; normally T expressed; and presumably secreted; SIS delta; SISd; small inducible cytokine subfamily A (Cys Cys); member 5; T cell specific protein p288; T cell specific RANTES protein; TCP228; eoCP; SIS-delta; beta-chemokine RANTES; small-inducible cytokine A5; T-cell specific protein p288; t cell-specific protein P228; T-cell-specific protein RANTES; eosinophil chemotactic cytokine; small inducible cytokine A5 (RANTES); small inducible cytokine subfamily A (Cys-Cys), member 5; regulated upon activation, normally T-expressed, and presumably secreted; SCYA5; D17S136E; |
Gene ID : | 6352 |
mRNA Refseq : | NM_002985 |
Protein Refseq : | NP_002976 |
MIM : | 187011 |
UniProt ID : | P13501 |
Chromosome Location : | 17q11.2-q12 |
Pathway : | Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; |
Function : | CCR1 chemokine receptor binding; CCR1 chemokine receptor binding; CCR1 chemokine receptor binding; CCR4 chemokine receptor binding; CCR5 chemokine receptor binding; chemoattractant activity; chemokine activity; chemokine activity; chemokine receptor antagonist activity; chemokine receptor binding; heparin binding; phosphatidylinositol phospholipase C activity; phospholipase activator activity; protein homodimerization activity; protein kinase activity; protein self-association; receptor signaling protein tyrosine kinase activator activity; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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