Active Recombinant Human CD163, His-tagged

• Cat.No.: CD163-112H
• Product Overview: Recombinant Human CD163 (Gly41-Ser1045), fused with a C-terminal 10-His tag, was expressed in NSO Cells.

Specification

• Description: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: His
• Predicted N Terminal: Gly41
• Form: Lyophilized from a 0.2 μm filtered solution in PBS.
• Bio-activity: Measured by its ability to bind Haptoglobin/Hemoglobin (Hp/Hb) complexes.
• Molecular Mass: Predicted Molecular Mass: 110 kDaSDS-PAGE: 135-140 kDa, reducing conditions
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 °C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Reconstitution: Reconstitute at 250 μg/mL in sterile PBS.

Gene Information

• Gene Name: CD163 CD163 molecule [ Homo sapiens (human) ]
• Official Symbol: CD163
• Synonyms: CD163; M130; MM130; CD163 molecule; scavenger receptor cysteine-rich type 1 protein M130; hemoglobin scavenger receptor; macrophage-associated antigen
• Gene ID: 9332
• mRNA Refseq: NM_004244
• Protein Refseq: NP_004235
• MIM: 605545
• UniProt ID: Q86VB7
• Chromosome Location: 12p13.3
• Pathway: Binding and Uptake of Ligands by Scavenger Receptors; Scavenging of Heme from Plasma
• Function: protein binding; scavenger receptor activity