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Active Recombinant Human CD22 Protein (Asp 20 - Arg 687), His-tagged, FITC-Labeled

Cat.No. : CD22-335H
Product Overview : Recombinant Human CD22 Protein, His-tagged, FITC-Labeled is expressed from human HEK293 cells. It contains AA Asp 20 - Arg 687 (Accession # P20273-1). It is the FITC labeled form of Human Siglec-2 (Cat. No. CD2-H52H8). Predicted N-terminus: Asp 20. This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 77.0 kDa. The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. Conjugate (FITC): Excitation source: 488 nm spectral line, argon-ion laser; Excitation Wavelength: 488 nm; Emission Wavelength: 535 nm. The FITC to protein molar ratio is 1.5-3.5.
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  • Gene Information
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Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Bio-activity : Immobilized Anti-Human CD22 MAb at 10 μg/mL (100 μL/well) can bind FITC-Labeled Human Siglec-2 (Cat. No. SI2-HF2H6) with a linear range of 0.625-10 μg/mL (Ex.488 nm/Em.535 nm) (QC tested).
Molecular Mass : 77.0 kDa
Protein length : Asp 20 - Arg 687
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Notes : Please avoid repeated freeze-thaw cycles.
Stability : No activity loss is observed after storage at:
4-8 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4 centigrade before opening to recover the entire contents.
Gene Name : CD22 CD22 molecule [ Homo sapiens ]
Official Symbol : CD22
Synonyms : CD22; CD22 molecule; CD22 antigen; B-cell receptor CD22; SIGLEC 2; SIGLEC2; BL-CAM; SIGLEC-2; FLJ22814; MGC130020;
Gene ID : 933
mRNA Refseq : NM_001185099
Protein Refseq : NP_001172028
MIM : 107266
UniProt ID : P20273

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does CD22-targeted immunotherapy differ from traditional chemotherapy? 02/05/2023

CD22-targeted immunotherapy is more targeted, specifically attacking cancer cells, whereas chemotherapy affects both healthy and cancerous cells.

Can CD22-targeted therapies be used in combination with other cancer treatments? 01/09/2023

Yes, CD22-targeted therapies are often used in combination with chemotherapy or other immunotherapies for enhanced efficacy.

What other diseases involve CD22 as a therapeutic target? 10/08/2020

CD22-targeted therapies are being explored for autoimmune diseases like rheumatoid arthritis and systemic lupus erythematosus.

Are there any clinical applications of CD22 protein in cancer therapy? 01/11/2019

Yes, CD22 is targeted in immunotherapy for B cell malignancies like acute lymphoblastic leukemia (ALL).

What role does CD22 play in B cell function? 05/13/2018

CD22 acts as an inhibitory receptor, regulating B cell activation and signaling.

Customer Reviews (3)

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Reviews
01/15/2021

    The CD22 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.

    06/15/2017

      Its unique properties make CD22 an invaluable tool for investigating cellular signaling pathways, protein-protein interactions, and membrane dynamics.

      02/17/2016

        With the CD22 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.

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