| Description : |
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
95.8 kDa |
| AA Sequence : |
MHLLGPWLLLLVLEYLAFSDSSKWV FEHPETLYAWEGACVWIPCTYRALD GDLESFILFHNPEYNKNTSKFDGTR LYESTKDGKVPSEQKRVQFLGDKNK NCTLSIHPVHLNDSGQLGLRMESKT EKWMERIHLNVSERPFPPHIQLPPE IQESQEVTLTCLLNFSCYGYPIQLQ WLLEGVPMRQAAVTSTSLTIKSVFT RSELKFSPQWSHHGKIVTCQLQDAD GKFLSNDTVQLNVKHTPKLEIKVTP SDAIVREGDSVTMTCEVSSSNPEYT TVSWLKDGTSLKKQNTFTLNLREVT KDQSGKYCCQVSNDVGPGRSEEVFL QVQYAPEPSTVQILHSPAVEGSQVE FLCMSLANPLPTNYTWYHNGKEMQG RTEEKVHIPKILPWHAGTYSCVAEN ILGTGQRGPGAELDVQYPPKKVTTV IQNPMPIREGDTVTLSCNYNSSNPS VTRYEWKPHGAWEEPSLGVLKIQNV GWDNTTIACAACNSWCSWASPVALN VQYAPRDVRVRKIKPLSEIHSGNSV SLQCDFSSSHPKEVQFFWEKNGRLL GKESQLNFDSISPEDAGSYSCWVNN SIGQTASKAWTLEVLYAPRRLRVSM SPGDQVMEGKSATLTCESDANPPVS HYTWFDWNNQSLPYHSQKLRLEPVK VQHSGAYWCQGTNSVGKGRSPLSTL TVYYSPETIGRRVAVGLGSCLAILI LAICGLKLQRRWKRTQSQQGLQENS SGQSFFVRNKKVRRAPLSEGPHSLG CYNPMMEDGISYTTLRFPEMNIPRT GDAESSEMQRPPPDCDDTVTYSALH KRQVGDYENVIPDFPEDEGIHYSEL IQFGVGERPQAQENVDYVILKHTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
