Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human CD276 Protein, hFc-tagged, Alexa Fluor 488 conjugated

Cat.No. : CD276-2002HAF488
Product Overview : The Alexa Fluor 488 conjugated extracellular domain of human B7-H3 (NP_079516.1) (Leu29-Pro245) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in theregulation of T-cell-mediated immune response. Studies show that while the transcript of this gene isubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumortissues. Additionally, it was observed that the 3" UTR of this transcript contains a target site for miR29microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggestingregulation of expression of this gene product by miR29. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene.
Source : CHO
Species : Human
Tag : hFc
Form : Lyophilized
Bio-activity : Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
Molecular Mass : 49 kDa (monomer)
AA Sequence : Leu29-Pro245
Endotoxin : < 0.06 EU/ μg as determined by LAL test.
Purity : > 98 % by SDS-PAGE under reducing conditions.
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 488 via amines
Excitation Wavelength: 488 nm
Emission Wavelength: 515­-545 nm
Stability : Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade.
Concentration : 100 μg/mL
Storage Buffer : Lyophilized from 0.2 μm filtered solution in PBS.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Gene Name : CD276 CD276 molecule [ Homo sapiens ]
Official Symbol : CD276
Synonyms : CD276; CD276 molecule; CD276 antigen; B7 H3; B7H3; B7RP 2; B7 homolog 3; costimulatory molecule; B7-H3; B7RP-2; 4Ig-B7-H3;
Gene ID : 80381
mRNA Refseq : NM_001024736
Protein Refseq : NP_001019907
MIM : 605715
UniProt ID : Q5ZPR3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
In which other diseases, besides cancer, is CD276 implicated? 11/29/2022

CD276 has been associated with autoimmune diseases and certain inflammatory conditions. Exploring its role in these diseases may open avenues for therapeutic interventions.

Are there diagnostic applications for CD276 in cancer detection? 10/15/2021

Research suggests that CD276 expression levels may serve as a diagnostic biomarker for certain cancers. Detection methods, such as immunohistochemistry, are being explored to assess CD276 levels in tumor tissues.

How does CD276 influence the tumor microenvironment? 05/07/2020

CD276 can modulate the tumor microenvironment by suppressing immune responses, promoting angiogenesis, and supporting tumor cell survival. Understanding these interactions is crucial for developing targeted therapies.

Are there any ongoing clinical trials focusing on CD276 in cancer patients? 06/20/2016

Yes, several clinical trials are underway to evaluate the safety and efficacy of CD276-targeted therapies in different cancer types. These trials aim to assess the impact on patient outcomes and potential side effects.

How does CD276-targeted therapy differ from traditional cancer treatments? 02/14/2016

CD276-targeted therapy focuses on modulating the immune response against cancer cells, whereas traditional treatments like chemotherapy and radiation target rapidly dividing cells, including both healthy and cancerous cells.

Customer Reviews (3)

Write a review
Reviews
03/15/2022

    It has consistently demonstrated high sensitivity and accuracy in detecting and quantifying target molecules, allowing for precise and reliable measurement of analytes in my experimental samples.

    08/06/2021

      Its versatility and reliability make it an excellent choice for research applications, and I highly recommend it to fellow scientists.

      06/03/2021

        The sensitivity and specificity of the CD276 Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.

        Ask a Question for All CD276 Products

        Required fields are marked with *

        My Review for All CD276 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends