Active Recombinant Human CD276 Protein, MIgG2a mFc-tagged, Alexa Fluor 488 conjugated
Cat.No. : | CD276-2001HAF488 |
Product Overview : | The Alexa Fluor 488 conjugated extracellular domain of human B7-H3 (NP_079516.1) (Leu29-Pro245) is fused to the N-terminus of the Fc region of mouse IgG2a. |
Unit | |
Price | |
Qty |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3" UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | CHO |
Species : | Human |
Tag : | mFc |
Form : | Lyophilized |
Bio-activity : | Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells. |
Molecular Mass : | 49 kDa (monomer) |
AA Sequence : | Leu29-Pro245 |
Endotoxin : | < 0.06 EU/ μg as determined by LAL test. |
Purity : | > 98 % by SDS-PAGE under reducing conditions. |
Characteristic : | Disulfide-linked homodimer Labeled with Alexa Fluor 488 via amines Excitation Wavelength: 488 nm Emission Wavelength: 515-545 nm |
Stability : | Stable for at least 1 year after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. |
Concentration : | 100 μg/mL |
Storage Buffer : | Lyophilized from 0.2 μm filtered solution in PBS. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Gene Name : | CD276 CD276 molecule [ Homo sapiens ] |
Official Symbol : | CD276 |
Synonyms : | CD276; CD276 molecule; CD276 antigen; B7 H3; B7H3; B7RP 2; B7 homolog 3; costimulatory molecule; B7-H3; B7RP-2; 4Ig-B7-H3; |
Gene ID : | 80381 |
mRNA Refseq : | NM_001024736 |
Protein Refseq : | NP_001019907 |
MIM : | 605715 |
UniProt ID : | Q5ZPR3 |
Products Types
◆ Recombinant Protein | ||
CD276-600H | Recombinant Human CD276 Protein, Fc-tagged | +Inquiry |
CD276-3054H | Recombinant Human CD276 Protein, MYC/DDK-tagged | +Inquiry |
CD276-0766H | Recombinant Human CD276 Protein, His-Flag-StrepII-Tagged | +Inquiry |
CD276-02H | Recombinant Human CD276 Protein, C-Avi-His tagged, Biotinylated | +Inquiry |
CD276-1363H | Recombinant Human CD276 protein(Met1-Thr461), hFc-tagged, Biotinylated | +Inquiry |
◆ Lysates | ||
CD276-001MCL | Recombinant Mouse CD276 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionCD276 has been associated with autoimmune diseases and certain inflammatory conditions. Exploring its role in these diseases may open avenues for therapeutic interventions.
Research suggests that CD276 expression levels may serve as a diagnostic biomarker for certain cancers. Detection methods, such as immunohistochemistry, are being explored to assess CD276 levels in tumor tissues.
CD276 can modulate the tumor microenvironment by suppressing immune responses, promoting angiogenesis, and supporting tumor cell survival. Understanding these interactions is crucial for developing targeted therapies.
Yes, several clinical trials are underway to evaluate the safety and efficacy of CD276-targeted therapies in different cancer types. These trials aim to assess the impact on patient outcomes and potential side effects.
CD276-targeted therapy focuses on modulating the immune response against cancer cells, whereas traditional treatments like chemotherapy and radiation target rapidly dividing cells, including both healthy and cancerous cells.
Customer Reviews (3)
Write a reviewIt has consistently demonstrated high sensitivity and accuracy in detecting and quantifying target molecules, allowing for precise and reliable measurement of analytes in my experimental samples.
Its versatility and reliability make it an excellent choice for research applications, and I highly recommend it to fellow scientists.
The sensitivity and specificity of the CD276 Protein have consistently delivered robust and consistent results, enhancing the efficiency and accuracy of my experimental workflows.
Ask a Question for All CD276 Products
Required fields are marked with *
My Review for All CD276 Products
Required fields are marked with *
Inquiry Basket