Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Active Recombinant Human CD40LG Protein (116-261), N-FLAG tagged, Certified Serum Grade

Cat.No. : CD40LG-12H
Product Overview : Recombinant crtified Serum Grade human CD40L (aa 116-261) fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag was expressed in CHO.
Certified Serum Grade: Produced using certified high-quality FBS grade serum. Specifications of FBS include Traceability/Source, Sterile Filtered, Virus, Mycoplasma & Endotoxin Tested, Osmolality and Cell Culture Tested, Inactivation by γ-Irradiation.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
Source : CHO
Species : Human
Tag : N-FLAG
Form : Lyophilized
Bio-activity : Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: < 1 ng/mL). B cell expansion online protocol available.
Molecular Mass : ~35-40 kDa (SDS-PAGE)
Protein Length : 116-261
Endotoxin : < 0.01 EU/μg purified protein (LAL test, Lonza).
Purity : ≥95 % (SDS-PAGE)
Stability : Stable for at least 6 months after receipt when stored at -20 centigrade.
Working aliquots are stable for up to 3 months when stored at -20 centigrade.
Storage : Short Term Storage: -20 centigrade
Long Term Storage: -20 centigrade
Concentration : 1 mg/mL
Storage Buffer : Contains PBS
Handling : Avoid freeze/thaw cycles.
PBS containing at least 0.1 % BSA should be used for further dilutions.
Shipping : DRY ICE
Gene Name : CD40LG CD40 ligand [ Homo sapiens (human) ]
Official Symbol : CD40LG
Synonyms : CD40LG; CD40 ligand; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L; CD40 ligand; CD40 antigen ligand; CD40-L; T-B cell-activating molecule; T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor (ligand) superfamily member 5
Gene ID : 959
mRNA Refseq : NM_000074
Protein Refseq : NP_000065
MIM : 300386
UniProt ID : P29965

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any ongoing clinical trials targeting CD40LG for autoimmune diseases? 11/01/2022

Yes, there are clinical trials investigating the modulation of CD40LG in autoimmune diseases, exploring its potential role in regulating immune responses that contribute to autoimmunity.

Can CD40LG be a potential target for the treatment of infectious diseases? 02/27/2021

Yes, research suggests that CD40LG modulation might be a viable strategy in the development of treatments for infectious diseases by enhancing immune responses.

How does the interaction between CD40LG and its receptor CD40 influence antibody production? 11/20/2020

The interaction between CD40LG and CD40 is crucial for the activation of B cells, leading to the production of antibodies and the development of an effective immune response.

How is CD40LG involved in the regulation of inflammatory responses? 08/26/2020

CD40LG is involved in modulating inflammatory responses by influencing the activation and function of immune cells, contributing to the regulation of the immune system.

In what ways is CD40LG being explored for its potential in vaccine development? 04/20/2020

CD40LG is being investigated as an adjuvant in vaccine development, aiming to enhance the immune response and improve the efficacy of vaccines against various diseases.

Customer Reviews (3)

Write a review
Reviews
10/17/2022

    The reliable performance of the CD40LG protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

    01/01/2022

      Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.

      11/16/2020

        Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.

        Ask a Question for All CD40LG Products

        Required fields are marked with *

        My Review for All CD40LG Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends