Active Recombinant Human CD40LG Protein (116-261), N-FLAG tagged, Certified Serum Grade
Cat.No. : | CD40LG-12H |
Product Overview : | Recombinant crtified Serum Grade human CD40L (aa 116-261) fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag was expressed in CHO. Certified Serum Grade: Produced using certified high-quality FBS grade serum. Specifications of FBS include Traceability/Source, Sterile Filtered, Virus, Mycoplasma & Endotoxin Tested, Osmolality and Cell Culture Tested, Inactivation by γ-Irradiation. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. |
Source : | CHO |
Species : | Human |
Tag : | N-FLAG |
Form : | Lyophilized |
Bio-activity : | Induces B cells activation (as demonstrated by dose-dependent upregulation of CD86) (ED50: < 1 ng/mL). B cell expansion online protocol available. |
Molecular Mass : | ~35-40 kDa (SDS-PAGE) |
Protein Length : | 116-261 |
Endotoxin : | < 0.01 EU/μg purified protein (LAL test, Lonza). |
Purity : | ≥95 % (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. |
Storage : | Short Term Storage: -20 centigrade Long Term Storage: -20 centigrade |
Concentration : | 1 mg/mL |
Storage Buffer : | Contains PBS |
Handling : | Avoid freeze/thaw cycles. PBS containing at least 0.1 % BSA should be used for further dilutions. |
Shipping : | DRY ICE |
Gene Name : | CD40LG CD40 ligand [ Homo sapiens (human) ] |
Official Symbol : | CD40LG |
Synonyms : | CD40LG; CD40 ligand; IGM; IMD3; TRAP; gp39; CD154; CD40L; HIGM1; T-BAM; TNFSF5; hCD40L; CD40 ligand; CD40 antigen ligand; CD40-L; T-B cell-activating molecule; T-cell antigen Gp39; TNF-related activation protein; tumor necrosis factor (ligand) superfamily member 5 |
Gene ID : | 959 |
mRNA Refseq : | NM_000074 |
Protein Refseq : | NP_000065 |
MIM : | 300386 |
UniProt ID : | P29965 |
Products Types
◆ Recombinant Protein | ||
CD40LG-11H | Active Recombinant Human CD40LG Protein (116-261), N-FLAG tagged, Biotinylated | +Inquiry |
CD40LG-680R | Recombinant Rhesus monkey CD40LG Protein, His-tagged | +Inquiry |
CD40LG-567R | Recombinant Rhesus Macaque CD40LG Protein, His (Fc)-Avi-tagged | +Inquiry |
CD40LG-0815H | Recombinant Human CD40LG Protein | +Inquiry |
CD40LG-0818H | Recombinant Human CD40LG Protein, GST-Tagged | +Inquiry |
◆ Lysates | ||
CD40LG-1548MCL | Recombinant Mouse CD40LG cell lysate | +Inquiry |
CD40LG-1965HCL | Recombinant Human CD40LG cell lysate | +Inquiry |
CD40LG-001CCL | Recombinant Canine CD40LG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, there are clinical trials investigating the modulation of CD40LG in autoimmune diseases, exploring its potential role in regulating immune responses that contribute to autoimmunity.
Yes, research suggests that CD40LG modulation might be a viable strategy in the development of treatments for infectious diseases by enhancing immune responses.
The interaction between CD40LG and CD40 is crucial for the activation of B cells, leading to the production of antibodies and the development of an effective immune response.
CD40LG is involved in modulating inflammatory responses by influencing the activation and function of immune cells, contributing to the regulation of the immune system.
CD40LG is being investigated as an adjuvant in vaccine development, aiming to enhance the immune response and improve the efficacy of vaccines against various diseases.
Customer Reviews (3)
Write a reviewThe reliable performance of the CD40LG protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.
Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.
Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.
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