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Recombinant Human CDC45 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CDC45-768H
Product Overview : CDC45 MS Standard C13 and N15-labeled recombinant protein (NP_003495) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 65.6 kDa
AA Sequence : MFVSDFRKEFYEVVQSQRVLLFVAS DVDALCACKILQALFQCDHVQYTLV PVSGWQELETAFLEHKEQFHYFILI NCGANVDLLDILQPDEDTIFFVCDT HRPVNVVNVYNDTQIKLLIKQDDDL EVPAYEDIFRDEEEDEEHSGNDSDG SEPSEKRTRLEEEIVEQTMRRRQRR EWEARRRDILFDYEQYEYHGTSSAM VMFELAWMLSKDLNDMLWWAIVGLT DQWVQDKITQMKYVTDVGVLQRHVS RHNHRNEDEENTLSVDCTRISFEYD LRLVLYQHWSLHDSLCNTSYTAARF KLWSVHGQKRLQEFLADMGLPLKQV KQKFQAMDISLKENLREMIEESANK FGMKDMRVQTFSIHFGFKHKFLASD VVFATMSLMESPEKDGSGTDHFIQA LDSLSRSNLDKLYHGLELAKKQLRA TQQTIASCLCTNLVISQGPFLYCSL MEGTPDVMLFSRPASLSLLSKHLLK SFVCSTKNRRCKLLPLVMAAPLSME HGTVTVVGIPPETDSSDRKNFFGRA FEKAAESTSSRMLHNHFDLSVIELK AEDRSKFLDALISLLSTRTRPLEQK LISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CDC45 cell division cycle 45 [ Homo sapiens (human) ]
Official Symbol : CDC45
Synonyms : CDC45; cell division cycle 45 homolog (S. cerevisiae); CDC45 (cell division cycle 45, S.cerevisiae, homolog) like, CDC45 cell division cycle 45 like (S. cerevisiae), CDC45L, CDC45L2; cell division control protein 45 homolog; human CDC45; CDC45-related protein; cell division cycle 45-like 2; CDC45 cell division cycle 45 homolog; CDC45L; CDC45L2; PORC-PI-1;
Gene ID : 8318
mRNA Refseq : NM_003504
Protein Refseq : NP_003495
MIM : 603465
UniProt ID : O75419

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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