| Description : |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
97.46 kDa |
| AA Sequence : |
MGPWSRSLSALLLLLQVSSWLCQEP EPCHPGFDAESYTFTVPRRHLERGR VLGRVNFEDCTGRQRTAYFSLDTRF KVGTDGVITVKRPLRFHNPQIHFLV YAWDSTYRKFSTKVTLNTVGHHHRP PPHQASVSGIQAELLTFPNSSPGLR RQKRDWVIPPISCPENEKGPFPKNL VQIKSNKDKEGKVFYSITGQGADTP PVGVFIIERETGWLKVTEPLDRERI ATYTLFSHAVSSNGNAVEDPMEILI TVTDQNDNKPEFTQEVFKGSVMEGA LPGTSVMEVTATDADDDVNTYNAAI AYTILSQDPELPDKNMFTINRNTGV ISVVTTGLDRESFPTYTLVVQAADL QGEGLSTTATAVITVTDTNDNPPIF NPTTYKGQVPENEANVVITTLKVTD ADAPNTPAWEAVYTILNDDGGQFVV TTNPVNNDGILKTAKGLDFEAKQQY ILHVAVTNVVPFEVSLTTSTATVTV DVLDVNEAPIFVPPEKRVEVSEDFG VGQEITSYTAQEPDTFMEQKITYRI WRDTANWLEINPDTGAISTRAELDR EDFEHVKNSTYTALIIATDNGSPVA TGTGTLLLILSDVNDNAPIPEPRTI FFCERNPKPQVINIIDADLPPNTSP FTAELTHGASANWTIQYNDPTQESI ILKPKMALEVGDYKINLKLMDNQNK DQVTTLEVSVCDCEGAAGVCRKAQP VEAGLQIPAILGILGGILALLILIL LLLLFLRRRAVVKEPLLPPEDDTRD NVYYYDEEGGGEEDQDFDLSQLHRG LDARPEVTRNDVAPTLMSVPRYLPR PANPDEIGNFIDENLKAADTDPTAP PYDSLLVFDYEGSGSEAASLSSLNS SESDKDQDYDYLNEWGNRFKKLADM YGGGEDDTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
