Recombinant Human CES1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CES1-3468H
• Product Overview: CES1 MS Standard C13 and N15-labeled recombinant protein (NP_001257) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 62.39 kDa
• AA Sequence: MWLRAFILATLSASAAWGHPSSPPV VDTVHGKVLGKFVSLEGFAQPVAIF LGIPFAKPPLGPLRFTPPQPAEPWS FVKNATSYPPMCTQDPKAGQLLSEL FTNRKENIPLKLSEDCLYLNIYTPA DLTKKNRLPVMVWIHGGGLMVGAAS TYDGLALAAHENVVVVTIQYRLGIW GFFSTGDEHSRGNWGHLDQVAALRW VQDNIASFGGNPGSVTIFGESAGGE SVSVLVLSPLAKNLFHRAISESGVA LTSVLVKKGDVKPLAEQIAITAGCK TTTSAVMVHCLRQKTEEELLETTLK MKFLSLDLQGDPRESQPLLGTVIDG MLLLKTPEELQAERNFHTVPYMVGI NKQEFGWLIPMLMSYPLSEGQLDQK TAMSLLWKSYPLVCIAKELIPEATE KYLGGTDDTVKKKDLFLDLIADVMF GVPSVIVARNHRDAGAPTYMYEFQY RPSFSSDMKPKTVIGDHGDELFSVF GAPFLKEGASEEEIRLSKMVMKFWA NFARNGNPNGEGLPHWPEYNQKEGY LQIGANTQAAQKLKDKEVAFWTNLF AKKAVEKPPQTEHIELTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CES1 carboxylesterase 1 [ Homo sapiens (human) ]
• Official Symbol: CES1
• Synonyms: CES1; carboxylesterase 1; carboxylesterase 1 (monocyte/macrophage serine esterase 1); liver carboxylesterase 1; CEH; CES1A1; CES1A2; CES2; HMSE; HMSE1; human monocyte/macrophage serine esterase 1; SES1; egasyn; serine esterase 1; retinyl ester hydrolase; cocaine carboxylesterase; triacylglycerol hydrolase; carboxylesterase 2 (liver); brain carboxylesterase hBr1; cholesteryl ester hydrolase; monocyte/macrophage serine esterase; methylumbelliferyl-acetate deacetylase 1; acyl coenzyme A:cholesterol acyltransferase; acyl-coenzyme A:cholesterol acyltransferase; REH; TGH; ACAT; PCE-1; MGC117365
• Gene ID: 1066
• mRNA Refseq: NM_001266
• Protein Refseq: NP_001257
• MIM: 114835
• UniProt ID: P23141