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Recombinant Human CFL2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CFL2-6639H
Product Overview : CFL2 MS Standard C13 and N15-labeled recombinant protein (NP_619579) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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  • Gene Information
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Description : This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 18.7 kDa
AA Sequence : MASGVTVNDEVIKVFNDMKVRKSST QEEIKKRKKAVLFCLSDDKRQIIVE EAKQILVGDIGDTVEDPYTSFVKLL PLNDCRYALYDATYETKESKKEDLV FIFWAPESAPLKSKMIYASSKDAIK KKFTGIKHEWQVNGLDDIKDRSTLG EKLGGNVVVSLEGKPLTRTRPLEQK LISEEDLAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CFL2 cofilin 2 [ Homo sapiens (human) ]
Official Symbol : CFL2
Synonyms : CFL2; cofilin 2 (muscle); cofilin-2; cofilin, muscle isoform; NEM7;
Gene ID : 1073
mRNA Refseq : NM_138638
Protein Refseq : NP_619579
MIM : 601443
UniProt ID : Q9Y281

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing clinical trials targeting CFL2 for therapeutic purposes? 06/08/2022

It's important to check current clinical trial databases for the latest information, but research exploring CFL2 as a therapeutic target is ongoing.

How does CFL2 relate to cardiac diseases? 03/13/2022

CFL2 is involved in maintaining the structure and function of cardiac muscle cells, and its dysregulation has been linked to conditions such as cardiomyopathies.

Are there diagnostic applications for CFL2 in muscle-related disorders? 11/09/2018

Research suggests that analyzing CFL2 levels and activity could serve as diagnostic markers for certain muscle-related disorders.

How does CFL2 interact with other proteins in the context of muscle function? 04/13/2018

CFL2 interacts with actin and other regulatory proteins to modulate the dynamics of the actin cytoskeleton, influencing cellular processes crucial for muscle function.

Can CFL2 be a potential therapeutic target for muscle-related disorders? 02/28/2017

Investigating CFL2 as a therapeutic target is an active area of research, with the aim of developing interventions for conditions characterized by impaired muscle function.

Customer Reviews (3)

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Reviews
05/23/2022

    It has been extensively used in protein-protein interaction studies, enzymatic assays, and structural analyses, showcasing its reliability and adaptability in diverse research areas.

    11/13/2021

      I am certain of obtaining reliable and reproducible results, enabling me to contribute to scientific progress and make new discoveries.

      11/07/2017

        I highly recommend the CFL2 Protein for its outstanding performance in ELISA assays.

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