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Recombinant Human Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha), His-tagged
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Cat.No. : | CXCL1-196H Optional Service: Optional requirements on this protein |
Product Overview : | A DNA sequence encoding the mature form of human CXCL1 ( P09341-1) ( Ala 35-Asn 107 ) was fused with a N-terminal polyhistide-tagged SUMO tag at the N-terminus |
Description : | The Chemokine ( C-X-C motif ) Ligand 1, CXCL1, also known as melanoma growth-stimulatory activity/growth-regulated protein alpha (MGSA-a), a memer of CXC chemokine family, plays a major role in inflammation, angiogenesis, tumorigenesis, and wound healing. Recently, it have been extensively related to cellular transformation, tumor growth, homing, and metastasis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine CXCL1 elicits its effects by signaling through the chemokine receptor CXCR2. |
Source : | Human |
Host : | E. coli |
Form : | Lyophilized from sterile PBS, pH 7.4 , 10% glycerol Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. |
Purity : | > 97 % as determined by SDS-PAGE |
Endotoxin : | μ1.0 EU per μg protein as determined by the LAL method |
Stability : | Samples are stable for up to twelve months from date of receipt at -70 μ |
Predicted N terminal : | Met |
Molecular Mass : | The recombinant human CXCL1 consisting of 189 amino acids and has a calculated molecular mass of 21.3KDa. It migrates as an 30 kDa band in SDS-PAGE under reducing conditions |
Storage : | Store it under sterile conditions at -70μ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. |
PDBrendering based on 1mgs. : |
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Gene Name : | CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Homo sapiens ] |
Official Symbol : | CXCL1 |
Synonyms : | CXCL1; FSP; GRO; GRO-alpha(1-73); GRO1; GROA; MGSA; MGSA-a; NAP-3; SCYB1; C-X-C motif chemokine 1; GRO1 oncogene (melanoma growth stimulating activity, alpha) ; GRO1 oncogene (melanoma growth-stimulating activity) ; MGSA alpha; Melanoma growth stimulatory activity; Neutrophil-activating protein 3; chemokine (C-X-C motif) ligand 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); fibroblast secretory protein; melanoma growth stimulatory activity alpha; CXCL1; Growth-regulated alpha protein |
Gene ID : | 2919 |
mRNA Refseq : | NM_001511 |
Protein Refseq : | NP_001502 |
MIM : | 155730 |
UniProt ID : | P09341 |
Chromosome Location : | 4q21 |
Pathway : | Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Signaling by GPCR |
Function : | chemokine activity; enzyme activator activity; growth factor activity |
◆ Recombinant Protein
CXCL1-53H | Recombinant Human CXCL1 Protein | +Inquiry |
CXCL1-001H | Recombinant Human CXCL1 Protein, MBP-tagged | +Inquiry |
Cxcl1-068M | Recombinant Mouse Cxcl1 Protein | +Inquiry |
Cxcl1-53M | Recombinant Mouse CXCL1 Protein | +Inquiry |
CXCL1-52H | Recombinant Active Human CXCL1 Protein, His-tagged(N-ter) | +Inquiry |
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◆ Native Protein
CXCL1-27707TH | Native Human CXCL1 | +Inquiry |
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◆ Lysates
CXCL1-425HCL | Recombinant Human CXCL1 cell lysate | +Inquiry |
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CXCL1Cxcl10CXCL11CXCL12CXCL13CXCL14Cxcl15Cxcl16Cxcl2CXCL3Cxcl5CXCL6CXCL9Cxcl17CXCL7
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