Recombinant Human Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha), His-tagged CXCL1-196H

Recombinant Human Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha), His-tagged

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Cat.No. : CXCL1-196H Optional Service: Optional requirements on this protein
Product Overview : A DNA sequence encoding the mature form of human CXCL1 ( P09341-1) ( Ala 35-Asn 107 ) was fused with a N-terminal polyhistide-tagged SUMO tag at the N-terminus
Description : The Chemokine ( C-X-C motif ) Ligand 1, CXCL1, also known as melanoma growth-stimulatory activity/growth-regulated protein alpha (MGSA-a), a memer of CXC chemokine family, plays a major role in inflammation, angiogenesis, tumorigenesis, and wound healing. Recently, it have been extensively related to cellular transformation, tumor growth, homing, and metastasis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine CXCL1 elicits its effects by signaling through the chemokine receptor CXCR2.
Source : Human
Host : E. coli
Form : Lyophilized from sterile PBS, pH 7.4 , 10% glycerol Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.
Purity : > 97 % as determined by SDS-PAGE
Endotoxin : μ1.0 EU per μg protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70 μ
Predicted N terminal : Met
Molecular Mass : The recombinant human CXCL1 consisting of 189 amino acids and has a calculated molecular mass of 21.3KDa. It migrates as an 30 kDa band in SDS-PAGE under reducing conditions
Storage : Store it under sterile conditions at -70μ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
PDBrendering based on 1mgs. :

Gene Name : CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Homo sapiens ]
Official Symbol : CXCL1
Synonyms : CXCL1; FSP; GRO; GRO-alpha(1-73); GRO1; GROA; MGSA; MGSA-a; NAP-3; SCYB1; C-X-C motif chemokine 1; GRO1 oncogene (melanoma growth stimulating activity, alpha) ; GRO1 oncogene (melanoma growth-stimulating activity) ; MGSA alpha; Melanoma growth stimulatory activity; Neutrophil-activating protein 3; chemokine (C-X-C motif) ligand 1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); fibroblast secretory protein; melanoma growth stimulatory activity alpha; CXCL1; Growth-regulated alpha protein
Gene ID : 2919
mRNA Refseq : NM_001511
Protein Refseq : NP_001502
MIM : 155730
UniProt ID : P09341
Chromosome Location : 4q21
Pathway : Cytokine-cytokine receptor interaction; Epithelial cell signaling in Helicobacter pylori infection; Signaling by GPCR
Function : chemokine activity; enzyme activator activity; growth factor activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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