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Recombinant Human CHI3L1 Protein, MYC/DDK-tagged, C13 and N15-labeled

Cat.No. : CHI3L1-044H
Product Overview : CHI3L1 MS Standard C13 and N15-labeled recombinant protein (NP_001267) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in the process of inflammation and tissue remodeling.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 42.6 kDa
AA Sequence : MGVKASQTGFVVLVLLQCCSAYKLV CYYTSWSQYREGDGSCFPDALDRFL CTHIIYSFANISNDHIDTWEWNDVT LYGMLNTLKNRNPNLKTLLSVGGWN FGSQRFSKIASNTQSRRTFIKSVPP FLRTHGFDGLDLAWLYPGRRDKQHF TTLIKEMKAEFIKEAQPGKKQLLLS AALSAGKVTIDSSYDIAKISQHLDF ISIMTYDFHGAWRGTTGHHSPLFRG QEDASPDRFSNTDYAVGYMLRLGAP ASKLVMGIPTFGRSFTLASSETGVG APISGPGIPGRFTKEAGTLAYYEIC DFLRGATVHRILGQQVPYATKGNQW VGYDDQESVKSKVQYLKDRQLAGAM VWALDLDDFQGSFCGQDLRFPLTNA IKDALAATTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CHI3L1 chitinase 3 like 1 [ Homo sapiens (human) ]
Official Symbol : CHI3L1
Synonyms : CHI3L1; chitinase 3 like 1; ASRT7; CGP-39; GP-39; GP39; HC-gp39; HCGP-3P; hCGP-39; YK-40; YKL-40; YKL40; YYL-40; chitinase-3-like protein 1; 39 kDa synovial protein; cartilage glycoprotein 39; chitinase 3-like 1 (cartilage glycoprotein-39)
Gene ID : 1116
mRNA Refseq : NM_001276
Protein Refseq : NP_001267
MIM : 601525
UniProt ID : P36222

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Is there any other mode of action for CHI3L1? 01/05/2022

In addition to being involved in cartilage metabolism and immune regulation, CHI3L1 may also have other modes of action, such as regulating cell adhesion and migration.

What is the role of CHI3L1 in immune regulation? 07/11/2021

This protein can act as an immunomodulator to inhibit the inflammatory response and the activity of immune cells, thereby maintaining the balance of the immune system.

Does CHI3L1 involved in the metabolism and repair of cartilage? 04/15/2021

CHI3L1 can bind to receptors on the surface of chondrocytes, stimulate the proliferation and differentiation of chondrocytes, and promote cartilage synthesis and repair.

How is the expression level of CHI3L1 regulated? 03/20/2021

The expression level of CHI3L1 is regulated by a variety of factors, including transcription factors, signal transduction pathways, and epigenetic modifications.

What is the association between CHI3L1 and joint diseases such as rheumatoid arthritis? 04/26/2020

In joint diseases such as rheumatoid arthritis, the expression level of CHI3L1 may be abnormally elevated, promoting inflammation and joint damage, and aggravating the condition.

How to detect the expression level of CHI3L1? 12/16/2019

The expression level of CHI3L1 can be detected by immunohistochemistry, western blotting, and real-time PCR.

Customer Reviews (3)

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Reviews
12/15/2022

    CHI3L1 has strong biological activity combined with its high purity makes its experimental results extremely reliable.

    10/22/2022

      The band strength in Western blot was high, which improved the signal-to-noise ratio of the experiment.

      10/24/2021

        It can simplify the complex chemical reaction and improve the high yield, shorten the experimental time.

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