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Active Recombinant Human COMT Protein, His-tagged

Cat.No. : COMT-1707H
Product Overview : Recombinant Human COMT protein was expressed in E. coli with His tag.
  • Specification
  • Gene Information
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Description : Catechol-O-methyltransferase (COMT) catalyzes the transfer of the methyl group from S-adenosyl-L-methionine to either the meta- or the para-hydroxyl group of the catechol ring from a variety of endogenous and exogenous catechol substrates including the neurotransmitters dopamine, epinephrine, and norepinephrine. Thus, it plays important roles in one of the major degradative pathways of the catecholamine transmitters, and in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson’s disease. In tissues, COMT is produced as two distinct forms, a soluble protein (residues 52-271) and a membrane-bound protein that possesses the N-terminal transmembrane domain. A common single-nucleotide polymorphism results in substitution of methionine for valine at position 158 of membrane-bound COMT and position 108 at soluble COMT. This amino acid change results in a more unstable and three- to four-fold less active 108/158Met form. Since COMT activity is the major regulator of dopamine function in the prefrontal brain region, the Val108/158Met variation is considered to be associated with increased risk of a wide spectrum of mental disorders.
Source : E. coli
Species : Human
Tag : His
Form : 0.2 μm filtered solution in Tris, NaCl and Glycerol.
Bio-activity : Measured by its ability to methylate catechol to O-methyl-catechol. The specific activity is >95 pmol/min/μg.
Molecular Mass : 25 kDa
Endotoxin : <0.10 EU per 1 μg of the protein by the LAL method.
Purity : > 90%
Storage : 6 months from date of receipt, -20 to -70 centigrade as supplied. 3 months, -20 to -70 centigrade under sterile conditions after opening.
Gene Name : COMT catechol-O-methyltransferase [ Homo sapiens ]
Official Symbol : COMT
Synonyms : COMT; catechol-O-methyltransferase; EC 2.1.1.6
Gene ID : 1312
mRNA Refseq : NM_000754
Protein Refseq : NP_000745
MIM : 116790
UniProt ID : P21964

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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07/06/2021

    Its purity, stability, and functionality make it an ideal choice for my research endeavors.

    09/16/2019

      The COMT protein offered by the manufacturer exhibits exceptional quality and is precisely tailored to meet my experimental requirements.

      04/09/2016

        Manufacturers should ensure the consistency and quality of COMT protein products.

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