"CSF1R" Related Products

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Recombinant Human CSF1R protein, Fc-tagged

Cat.No.: CSF1R-470H
Product Overview: Recombinant Human CSF1R(Ile 20 - Glu 512) fused with a human IgG1 Fc tag at the C-terminus was expressed in HEK293.
Source: HEK293
Species: Human
Tag: Fc
Predicted N Terminal: Ile 20
Form: Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH7.5. Normally Trehalose is added as protectant before lyophilization.
Bio-activity: Measured by its ability to inhibit the MCSF-induced proliferation of NFS-60 mouse myelogenous leukemia lymphoblast cells.The ED50 for this effect is typically 4-12 pg/mL in the presence of 1 ng/mL of rhMCSF.
Molecular Mass: Has a calculated MW of 80.7 kDa. The reducing (R) protein migrates as 95-150 kDa in SDS-PAGE due to glycosylation.
Protein length: Ile 20 - Glu 512
Endotoxin: Less than 0.1 EU per μg by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).
Gene Name: CSF1R colony stimulating factor 1 receptor [ Homo sapiens ]
Official Symbol: CSF1R
Synonyms: CSF1R; colony stimulating factor 1 receptor; FMS, McDonough feline sarcoma viral (v fms) oncogene homolog; macrophage colony-stimulating factor 1 receptor; C FMS; CD115; CSFR; CSF-1-R; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; proto-oncogene c-Fms; macrophage colony stimulating factor I receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; FMS; FIM2; HDLS; C-FMS; CSF-1R; M-CSF-R;
Gene ID: 1436
mRNA Refseq: NM_005211
Protein Refseq: NP_005202
MIM: 164770
UniProt ID: P07333
Chromosome Location: 5q32
Pathway: C-MYB transcription factor network, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem;
Function: ATP binding; cytokine binding; cytokine binding; macrophage colony-stimulating factor receptor activity; nucleotide binding; protein homodimerization activity; receptor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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