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Recombinant Human CX3CL1 protein, His-tagged

Cat.No. : CX3CL1-399H
Product Overview : Recombinant Human CX3CL1 protein (Gln25-Gln341), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293).
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  • Gene Information
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Description : Fractalkine is also known as C-X3-C motif chemokine 1 (CX3CL1) and neurotactin. Fractalkine is a large cytokine protein of 373 amino acids, it contains multiple domains and is the only known member of the CX3C chemokine family. Fractalkine is found commonly throughout the brain, particularly in neural cells, and its receptor is known to be present on microglial cells. It has also been found to be essential for microglial cell migration. CX3CL1 is also up-regulated in the hippocampus during a brief temporal window following spatial learning, the purpose of which may be to regulate glutamate-mediated neurotransmission tone. This indicates a possible role for the chemokine in the protective plasticity process of synaptic scaling.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 35.5 kDa. The protein migrates as 50-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 317
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : CX3CL1
Official Symbol : CX3CL1
Synonyms : CX3CL1; chemokine (C-X3-C motif) ligand 1; SCYD1, small inducible cytokine subfamily D (Cys X3 Cys), member 1 (fractalkine, neurotactin); fractalkine; ABCD 3; C3Xkine; CXC3; CXC3C; neurotactin; NTN; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); NTT; SCYD1; ABCD-3
Gene ID : 6376
mRNA Refseq : NM_002996
Protein Refseq : NP_002987
MIM : 601880
UniProt ID : P78423

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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In what ways is CX3CL1 linked to the modulation of pain perception and neuropathic pain conditions? 04/30/2021

CX3CL1 is involved in pain modulation, and its dysregulation is associated with neuropathic pain conditions. Understanding its role may lead to the development of novel analgesic therapies.

Are there any ongoing clinical trials targeting CX3CL1 for therapeutic purposes? 09/14/2020

Yes, several clinical trials are investigating the therapeutic potential of targeting CX3CL1 in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.

In cardiovascular diseases, how does CX3CL1 impact inflammation and vascular function? 03/23/2020

CX3CL1 contributes to inflammation in cardiovascular diseases and affects vascular function. Studying its role helps in understanding the pathophysiology of conditions like atherosclerosis.

How does CX3CL1 influence the recruitment and activation of immune cells in the context of inflammation? 01/06/2019

CX3CL1 acts as a chemoattractant, facilitating the recruitment and activation of immune cells at the site of inflammation, playing a pivotal role in immune response regulation.

How is CX3CL1 being investigated for its potential as a biomarker in various diseases? 05/19/2016

Researchers are exploring CX3CL1 as a potential biomarker for diseases such as rheumatoid arthritis and certain cancers, aiming to develop diagnostic tools and monitor disease progression.

Customer Reviews (3)

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Reviews
03/15/2022

    the CX3CL1 protein's compatibility with various experimental techniques further supports its usability.

    08/06/2021

      One of the standout features of the CX3CL1 protein is the excellent technical support provided by the manufacturer.

      06/03/2021

        Whether I need to study protein-protein interactions, protein localization, or protein folding, the CX3CL1 protein consistently delivers precise and meaningful data.

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