Recombinant Human CXCL11 Protein (74 aa) CXCL11-347C

Recombinant Human CXCL11 Protein (74 aa)


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Recombinant Human CXCL11 Protein (74 aa)

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Cat.No. : CXCL11-347C Optional Service: Optional requirements on this protein
Product Overview : Recombinant human I-TAC/CXCL11 (rhI-TAC) produced in E. coli is a single non-glycosylated polypeptide chain containing 74 amino acids. A fully biologically active molecule, rhI-TAC has a molecular mass of 8.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
Description : I-TAC (Interferon-inducible T-cell α Chemoattractant), also known as CXCL11, is a chemokine belonging to the CXCL subfamily. Along with Interferon-γ induced Protein 10 kDa and Monokine Induced by Interferon-γ, I-TAC is strongly up-regulated by Interferon-γ and binds to the G-protein coupled receptor CXCR3. The expression of CXCR3 is associated with Th1-mediated immune responses and mediates chemotaxis of Th1 cells. I-TAC induces, maintains, and amplifies the inflammatory reactions, and sustains chronic immune responses against self-antigens. Although CXCR3 was thought to be the exclusive receptor of I-TAC initially, more evidence has shown that I-TAC can also bind to CXCR4 and CXCR7, and that I-TAC plays important roles in tumor development and angiostasis.
Source : E. coli
Species : Human
Form : Sterile Filtered White lyophilized (freeze-dried) powder.
Bio-activity : ED50 < 2.5 μg/mL, measured by the FLIPR assay using CHO cells transfected with human CXCR3, the receptor of human CXCL11, corresponding to a specific activity of > 400 units/mg.
Molecular Mass : 8.4 kDa, observed by reducing SDS-PAGE.
Protein Length : 74
Endotoxin : < 0.2 EU/μg, determined by LAL method.
Purity : > 95% as analyzed by SDS-PAGE and HPLC.
Storage : Lyophilized recombinant human I-TAC/CXCL11 (rhI-TAC) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rhI-TAC remains stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade.
Storage Buffer : Lyophilized after extensive dialysis against PBS.
Reconstitution : Reconstituted in ddH2O at 100 μg/mL.
Gene Name : CXCL11 chemokine (C-X-C motif) ligand 11 [ Homo sapiens ]
Official Symbol : CXCL11
Synonyms : CXCL11; chemokine (C-X-C motif) ligand 11; SCYB9B, SCYB11, small inducible cytokine subfamily B (Cys X Cys), member 11; C-X-C motif chemokine 11; b R1; H174; I TAC; IP 9; beta-R1; small inducible cytokine B11; small-inducible cytokine B11; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B; IP9; IP-9; b-R1; I-TAC; SCYB11; SCYB9B; MGC102770;
Gene ID : 6373
mRNA Refseq : NM_005409
Protein Refseq : NP_005400
MIM : 604852
UniProt ID : O14625
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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