Recombinant Human CXCL9, His-tagged CXCL9-9165H

Recombinant Human CXCL9, His-tagged

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Cat.No. : CXCL9-9165H Optional Service: Optional requirements on this protein
Product Overview : Recombinant human CXCL9 protein, a DNA sequence encoding human CXCL9 (Q07325) corresponding to amino acid (1-125) was expressed with a C-terminal polyhistidine tag in HEK293.
Description : C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, HuMIG, Small-inducible cytokine B9 and CXCL9, is a secreted protein which belongs to the?intercrine alpha (chemokine CxC) family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases.?CXCL9 is a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. CXCL9 binds to CXCR3. CXCR3 ligand CXCL9 is involved in regulation of the allergic response in the lung by regulation of lymphocyte activation and eosinophil recruitment. CXCL9 has immunomodulatory functions that are not mediated through a G-protein coupled receptor and may possess additional roles in host defenses against infection. Measurement of pretransplant serum CXCL9 levels might represent the tracking of a clinically useful parameter to identify subjects at high risk of acute rejection (AR) and graft failure. CXCL9 might be used for the individualization of immunosuppressive therapies.
Source : HEK293
Species : Human
Tag : His
Form : liquid. PBS pH7.4
Molecular Mass : The mature form of human CXCL9 consists of 103 amino acids (Thr23-Thr125) and has a predicted molecular mass of 11.9kDa. In SDS-PAGE under reducing conditions, it migrates with an apparent molecular mass of 18KDa.
Protein length : 1-125a.a
AA Sequence : MKKSGVLFLL GIILLVLIGV QGTPVVRKGR CSCISTNQGT IHLQSLKDLK QFAPSPSCEK IEIIATLKNG VQTCL NPDSADVKEL IKKWEKQVSQ KKKQKNGKKH QKKKVLKVRK SQRSRQKKTT
Purity : >90% as determined by SDS-PAGE
Storage : Store it at +4℃ for short term. For long term storage, store it at -20℃~-70℃
Concentration : 4 mg/ml
Gene Name : CXCL9 chemokine (C-X-C motif) ligand 9 [ Homo sapiens ]
Official Symbol : CXCL9
Synonyms : CXCL9; chemokine (C-X-C motif) ligand 9; CMK, MIG, monokine induced by gamma interferon; C-X-C motif chemokine 9; crg 10; Humig; SCYB9; small-inducible cytokine B9; gamma-interferon-induced monokine; monokine induced by gamma interferon; monokine induced by interferon-gamma; CMK; MIG; crg-10;
Gene ID : 4283
mRNA Refseq : NM_002416
Protein Refseq : NP_002407
MIM : 601704
UniProt ID : Q07325
Chromosome Location : 4q21
Pathway : CXCR3-mediated signaling events, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function : chemokine activity; cytokine activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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