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Recombinant Human CXCR2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CXCR2-5491H
Product Overview : CXCR2 MS Standard C13 and N15-labeled recombinant protein (NP_001548) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 40.8 kDa
AA Sequence : MEDFNMESDSFEDFWKGEDLSNYSY SSTLPPFLLDAAPCEPESLEINKYF VVIIYALVFLLSLLGNSLVMLVILY SRVGRSVTDVYLLNLALADLLFALT LPIWAASKVNGWIFGTFLCKVVSLL KEVNFYSGILLLACISVDRYLAIVH ATRTLTQKRYLVKFICLSIWGLSLL LALPVLLFRRTVYSSNVSPACYEDM GNNTANWRMLLRILPQSFGFIVPLL IMLFCYGFTLRTLFKAHMGQKHRAM RVIFAVVLIFLLCWLPYNLVLLADT LMRTQVIQETCERRNHIDRALDATE ILGILHSCLNPLIYAFIGQKFRHGL LKILAIHGLISKDSLPKDSRPSFVG SSSGHTSTTLTRTRPLEQKLISEED LAANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CXCR2 C-X-C motif chemokine receptor 2 [ Homo sapiens (human) ]
Official Symbol : CXCR2
Synonyms : CXCR2; chemokine (C-X-C motif) receptor 2; IL8RB, interleukin 8 receptor, beta; C-X-C chemokine receptor type 2; CD182; CMKAR2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B; IL8R2; IL8RA; IL8RB; CDw128b;
Gene ID : 3579
mRNA Refseq : NM_001557
Protein Refseq : NP_001548
MIM : 146928
UniProt ID : P25025

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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