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Recombinant Human CYP17A1 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CYP17A1-4348H
Product Overview : CYP17A1 MS Standard C13 and N15-labeled recombinant protein (NP_000093) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 57.2 kDa
AA Sequence : MWELVALLLLTLAYLFWPKRRCPGA KYPKSLLSLPLVGSLPFLPRHGHMH NNFFKLQKKYGPIYSVRMGTKTTVI VGHHQLAKEVLIKKGKDFSGRPQMA TLDIASNNRKGIAFADSGAHWQLHR RLAMATFALFKDGDQKLEKIICQEI STLCDMLATHNGQSIDISFPVFVAV TNVISLICFNTSYKNGDPELNVIQN YNEGIIDNLSKDSLVDLVPWLKIFP NKTLEKLKSHVKIRNDLLNKILENY KEKFRSDSITNMLDTLMQAKMNSDN GNAGPDQDSELLSDNHILTTIGDIF GAGVETTTSVVKWTLAFLLHNPQVK KKLYEEIDQNVGFSRTPTISDRNRL LLLEATIREVLRLRPVAPMLIPHKA NVDSSIGEFAVDKGTEVIINLWALH HNEKEWHQPDQFMPERFLNPAGTQL ISPSVSYLPFGAGPRSCIGEILARQ ELFLIMAWLLQRFDLEVPDDGQLPS LEGIPKVVFLIDSFKVKIKVRQAWR EAQAEGSTTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CYP17A1 cytochrome P450 family 17 subfamily A member 1 [ Homo sapiens (human) ]
Official Symbol : CYP17A1
Synonyms : CYP17A1; cytochrome P450, family 17, subfamily A, polypeptide 1; CYP17, cytochrome P450, subfamily XVII (steroid 17 alpha hydroxylase), adrenal hyperplasia; steroid 17-alpha-hydroxylase/17,20 lyase; CPT7; P450C17; S17AH; Steroid 17 alpha monooxygenase; CYPXVII; cytochrome P450c17; cytochrome P450-C17; cytochrome P450 17A1; cytochrome p450 XVIIA1; steroid 17-alpha-monooxygenase; cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia; CYP17;
Gene ID : 1586
mRNA Refseq : NM_000102
Protein Refseq : NP_000093
MIM : 609300
UniProt ID : P05093

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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