Active Recombinant Human CYP1B1 Protein
Cat.No. : | CYP1B1-70H |
Product Overview : | Recombinant human CYP1B1 (Val-432) protein and CYP-reductase without tag were coexpressed in E. coli. |
- Specification
- Gene Information
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Description : | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. |
Source : | E. coli |
Species : | Human |
Bio-activity : | Cytochrome c Reductase Activity: 227 nmol/min/mg protein P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5 mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+ , 1 U/ml glucose 6-phosphate dehydrogenase]) Activity: 17β-estradiol 4-hydroxylase Linear with time up to: 20 min(Determined at 4 µM substrate, using a P450 concentration of 12.5 pmol/ml) Linear with P450 up to: 80 pmol/ml(Determined at 4 µM substrate, using an incubation time of 5 min) Vmax: 1.6 pmol/min/pmol CYP Km: 0.66 µM |
Usage : | For laboratory (research) purposes only |
Storage : | Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice. |
Concentration : | P450 Concentration: 5.8 nmol/ml Protein Concentration: 8.8 mg/ml Specific P450 Content: 659 pmol/mg protein |
Storage Buffer : | 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA |
Gene Name : | CYP1B1 cytochrome P450 family 1 subfamily B member 1 [ Homo sapiens (human) ] |
Official Symbol : | CYP1B1 |
Synonyms : | CYP1B1; cytochrome P450 family 1 subfamily B member 1; CP1B; ASGD6; GLC3A; CYPIB1; P4501B1; cytochrome P450 1B1; aryl hydrocarbon hydroxylase; cytochrome P450, family 1, subfamily B, polypeptide 1; cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile); dioxin-inducible cytochrome p450; flavoprotein-linked monooxygenase; hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; xenobiotic monooxygenase |
Gene ID : | 1545 |
mRNA Refseq : | NM_000104 |
Protein Refseq : | NP_000095 |
MIM : | 601771 |
UniProt ID : | Q16678 |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionIt plays a key role in detoxifying environmental carcinogens and pollutants.
CYP1B1 works alongside other P450 enzymes, contributing to a broad spectrum of metabolic processes.
Genetic mutations in CYP1B1 can lead to variations in metabolism, influencing drug response and toxicity.
Altered CYP1B1 activity is associated with an increased risk of certain cancers, due to its role in metabolizing carcinogens.
Targeting CYP1B1 offers potential for cancer prevention and treatment, particularly in managing hormone-related cancers.
CYP1B1, part of the cytochrome P450 family, is essential for metabolizing various drugs and chemicals.
CYP1B1 is involved in the metabolism of steroid hormones, affecting their synthesis and breakdown.
Customer Reviews (3)
Write a reviewTrustworthy data source. A critical research asset.
Reliable partner in experiments. Enhances research quality.
Dependable results. A research cornerstone.
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