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Recombinant Human CYP21A2 Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : CYP21A2-606H
Product Overview : CYP21A2 MS Standard C13 and N15-labeled recombinant protein (NP_000491) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 56 kDa
AA Sequence : MLLLGLLLLLPLLAGARLLWNWWKL QSLHLPPLAPGFLHLLQPDLPIYLL GLTQKFGPIYRLHLGLQDVVVLNSK RTIEEAMVKKWADFAGRPEPLTYKL VSRNYPDLSLGDYSLLWKAHKKLTR SALLLGIRDSMEPVVEQLTQEFCER MRAQPGTPVAIEEEFSLLTCSIICY LTFGDKIKDDNLMPAYYKCIQEVLK TWSHWSIQIVDVIPFLRFFPNPGLR RLKQAIEKRDHIVEMQLRQHKESLV AGQWRDMMDYMLQGVAQPSMEEGSG QLLEGHVHMAAVDLLIGGTETTANT LSWAVVFLLHHPEIQQRLQEELDHE LGPGASSSRVPYKDRARLPLLNATI AEVLRLRPVVPLALPHRTTRPSSIS GYDIPEGTVIIPNLQGAHLDETVWE RPHEFWPDRFLEPGKNSRALAFGCG ARVCLGEPLARLELFVVLTRLLQAF TLLPSGDALPSLQPLPHCSVILKMQ PFQVRLQPRGMGAHSPGQSQTRTRP LEQKLISEEDLAANDILDYKDDDDK V
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
Gene Name : CYP21A2 cytochrome P450 family 21 subfamily A member 2 [ Homo sapiens (human) ]
Official Symbol : CYP21A2
Synonyms : CYP21A2; cytochrome P450, family 21, subfamily A, polypeptide 2; CYP21, CYP21B, cytochrome P450, subfamily XXIA (steroid 21 hydroxylase, congenital adrenal hyperplasia), polypeptide 2; steroid 21-hydroxylase; CA21H; CAH1; CPS1; P450c21B; Steroid 21 monooxygenase; 21-OHase; cytochrome P450 21; cytochrome P450 XXI; cytochrome P450-C21B; steroid 21-monooxygenase; cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2; CYP21; CYP21B; MGC150536; MGC150537;
Gene ID : 1589
mRNA Refseq : NM_000500
Protein Refseq : NP_000491
MIM : 613815
UniProt ID : P08686

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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