Recombinant Human CYP2C9 Protein


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Recombinant Human CYP2C9 Protein

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Cat.No. : CYP2C9-74H
Product Overview : Recombinant human CYP2C9 protein and CYP-reductase without tag were coexpressed in E. coli.
Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Source : E. coli
Species : Human
Bio-activity : Cytochrome c Reductase Activity: 283 nmol/min/mg protein
P450 Activity Data(Unless otherwise stated, all assays are carried out at 37 centigrade in 50 mM potassium phosphate buffer (pH 7.4) containing 5mM magnesium chloride and an NADPH generating system [5 mM glucose 6-phosphate, 1 mM NADP+, 1 U/ml glucose 6-phosphate dehydrogenase])
Activity: Diclofenac 4’-hydroxylase
Linear with time up to: 15 min(Determined at 2.5 μM substrate, using a P450 concentration of 10 pmol/ml)
Linear with P450 up to: 25 pmol/ml(Determined at 2.5 μM substrate, using an incubation time of 5 min)
Vmax: 20 pmol/min/pmol CYP
Km: 1.8 μM
Usage : For laboratory (research) purposes only
Storage : Store at -80 centigrade. Avoid frequent temperature changes. Thaw on ice.
Concentration : P450 Concentration: 4.5 nmol/ml
Protein Concentration: 9.9 mg/ml
Specific P450 Content: 455 pmol/mg protein
Storage Buffer : 50 mM Tris-acetate (pH 7.6), 250 mM sucrose, 0.25 mM EDTA
Gene Name : CYP2C9 cytochrome P450 family 2 subfamily C member 9 [ Homo sapiens (human) ]
Official Symbol : CYP2C9
Synonyms : CYP2C9; cytochrome P450 family 2 subfamily C member 9; CPC9; CYP2C; CYP2C10; CYPIIC9; P450IIC9; cytochrome P450 2C9; cytochrome P-450 S-mephenytoin 4-hydroxylase; cytochrome P-450MP; cytochrome P450 PB-1; cytochrome P450, family 2, subfamily C, polypeptide 9; flavoprotein-linked monooxygenase; microsomal monooxygenase; xenobiotic monooxygenase
Gene ID : 1559
mRNA Refseq : NM_000771
Protein Refseq : NP_000762
MIM : 601130
UniProt ID : P11712

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◆ Assay kits

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