Recombinant Human CYP3A4 Full Length Transmembrane protein (Ala2-Ala503), His-tagged
Cat.No. : | CYP3A4-545H |
Product Overview : | Recombinant Human CYP3A4 Protein (NP_059488.2) (Ala2-Ala503) was produced by E. coli expression system. This protein was expressed with a polyhistidine tag at the N-terminus. |
- Specification
- Gene Information
- Related Products
Source : | In vitro E. coli expression system |
Species : | Human |
Tag : | His |
Form : | If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0. |
Molecular Mass : | 63.3 kDa |
Protein Length : | 2-503aa |
AA Sequence : | ALIPDLAMETWLLLAVSLVLLYLYG THSHGLFKKLGIPGPTPLPFLGNIL SYHKGFCMFDMECHKKYGKVWGFYD GQQPVLAITDPDMIKTVLVKECYSV FTNRRPFGPVGFMKSAISIAEDEEW KRLRSLLSPTFTSGKLKEMVPIIAQ YGDVLVRNLRREAETGKPVTLKDVF GAYSMDVITSTSFGVNIDSLNNPQD PFVENTKKLLRFDFLDPFFLSITVF PFLIPILEVLNICVFPREVTNFLRK SVKRMKESRLEDTQKHRVDFLQLMI DSQNSKETESHKALSDLELVAQSII FIFAGYETTSSVLSFIMYELATHPD VQQKLQEEIDAVLPNKAPPTYDTVL QMEYLDMVVNETLRLFPIAMRLERV CKKDVEINGMFIPKGVVVMIPSYAL HRDPKYWTEPEKFLPERFSKKNKDN IDPYIYTPFGSGPRNCIGMRFALMN MKLALIRVLQNFSFKPCKETQIPLK LSLGGLLQPEKPVVLKVESRDGTVS GA- |
Purity : | Greater than 85% as determined by SDS-PAGE. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Reconstitution : | Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. |
Gene Name : | CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 [ Homo sapiens ] |
Official Symbol : | CYP3A4 |
Synonyms : | CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; CYP3A3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450 3A4; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; MGC126680; |
Gene ID : | 1576 |
mRNA Refseq : | NM_001202855 |
Protein Refseq : | NP_001189784 |
MIM : | 124010 |
UniProt ID : | P08684 |
Products Types
◆ Recombinant Protein | ||
CYP3A4-2273H | Recombinant Human CYP3A4 Protein, GST-tagged | +Inquiry |
CYP3A4-128C | Active Recombinant Cynomolgus CYP3A4 Protein | +Inquiry |
CYP3A4-1301H | Recombinant Human CYP3A4 Protein, His-tagged | +Inquiry |
CYP3A4-81H | Active Recombinant Human CYP3A4 Protein | +Inquiry |
CYP3A4-983R | Recombinant Rhesus Macaque CYP3A4 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CYP3A4-436HCL | Recombinant Human CYP3A4 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-2142 | Cytochrome P450 3A4 Inhibitor Screening Kit | +Inquiry |
Kit-1918 | Cytochrome P450 3A4 (CYP3A4) Activity Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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- Reviews
Q&As (7)
Ask a questionVariability in CYP3A4 activity due to genetic, environmental, and health factors results in diverse drug responses among individuals.
CYP3A4 inhibitors can increase, while inducers can decrease drug levels, affecting their safety and effectiveness.
CYP3A4 is predominantly expressed in the liver and intestines.
CYP3A4 is crucial for breaking down and clearing a wide variety of drugs and toxins from the body.
Genetic polymorphisms in CYP3A4 can result in altered enzyme activity, impacting drug metabolism.
Managing CYP3A4-mediated interactions may involve using drug interaction databases, adjusting drug dosages, or choosing alternative medications.
CYP3A4 activity is generally lower in infants, peaks in childhood, and varies in adults.
Customer Reviews (3)
Write a reviewSuperior quality, highly recommend.
Worked well, as described.
Perfect for protein studies.
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