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Recombinant Human CYP3A4 Full Length Transmembrane protein (Ala2-Ala503), His-tagged

Cat.No. : CYP3A4-545H
Product Overview : Recombinant Human CYP3A4 Protein (NP_059488.2) (Ala2-Ala503) was produced by E. coli expression system. This protein was expressed with a polyhistidine tag at the N-terminus.
  • Specification
  • Gene Information
  • Related Products
Source : In vitro E. coli expression system
Species : Human
Tag : His
Form : If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Molecular Mass : 63.3 kDa
Protein Length : 2-503aa
AA Sequence : ALIPDLAMETWLLLAVSLVLLYLYG THSHGLFKKLGIPGPTPLPFLGNIL SYHKGFCMFDMECHKKYGKVWGFYD GQQPVLAITDPDMIKTVLVKECYSV FTNRRPFGPVGFMKSAISIAEDEEW KRLRSLLSPTFTSGKLKEMVPIIAQ YGDVLVRNLRREAETGKPVTLKDVF GAYSMDVITSTSFGVNIDSLNNPQD PFVENTKKLLRFDFLDPFFLSITVF PFLIPILEVLNICVFPREVTNFLRK SVKRMKESRLEDTQKHRVDFLQLMI DSQNSKETESHKALSDLELVAQSII FIFAGYETTSSVLSFIMYELATHPD VQQKLQEEIDAVLPNKAPPTYDTVL QMEYLDMVVNETLRLFPIAMRLERV CKKDVEINGMFIPKGVVVMIPSYAL HRDPKYWTEPEKFLPERFSKKNKDN IDPYIYTPFGSGPRNCIGMRFALMN MKLALIRVLQNFSFKPCKETQIPLK LSLGGLLQPEKPVVLKVESRDGTVS GA-
Purity : Greater than 85% as determined by SDS-PAGE.
Storage : Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Reconstitution : Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.
Gene Name : CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 [ Homo sapiens ]
Official Symbol : CYP3A4
Synonyms : CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; CYP3A3, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; cytochrome P450 3A4; nifedipine oxidase; cytochrome P450 3A3; cytochrome P450 HLp; cytochrome P450-PCN1; cytochrome P450 NF-25; albendazole sulfoxidase; quinine 3-monooxygenase; albendazole monooxygenase; P450-III, steroid inducible; glucocorticoid-inducible P450; taurochenodeoxycholate 6-alpha-hydroxylase; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3; cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4; HLP; CP33; CP34; CYP3A; NF-25; CYP3A3; P450C3; CYPIIIA3; CYPIIIA4; P450PCN1; MGC126680;
Gene ID : 1576
mRNA Refseq : NM_001202855
Protein Refseq : NP_001189784
MIM : 124010
UniProt ID : P08684

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CYP3A4-436HCL Recombinant Human CYP3A4 cell lysate +Inquiry

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◆ Assay kits
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does CYP3A4 contribute to inter-individual drug response variability? 02/13/2022

Variability in CYP3A4 activity due to genetic, environmental, and health factors results in diverse drug responses among individuals.

What is the impact of CYP3A4 inhibitors and inducers on drug effectiveness and safety? 01/07/2020

CYP3A4 inhibitors can increase, while inducers can decrease drug levels, affecting their safety and effectiveness.

Where is CYP3A4 most highly expressed? 09/09/2019

CYP3A4 is predominantly expressed in the liver and intestines.

What role does CYP3A4 play in drug metabolism? 04/03/2019

CYP3A4 is crucial for breaking down and clearing a wide variety of drugs and toxins from the body.

Are there common genetic polymorphisms in CYP3A4, and how do they affect enzyme activity? 01/23/2019

Genetic polymorphisms in CYP3A4 can result in altered enzyme activity, impacting drug metabolism.

How can CYP3A4-mediated drug interactions be managed? 01/02/2019

Managing CYP3A4-mediated interactions may involve using drug interaction databases, adjusting drug dosages, or choosing alternative medications.

How does CYP3A4 activity vary with age? 01/18/2018

CYP3A4 activity is generally lower in infants, peaks in childhood, and varies in adults.

Customer Reviews (3)

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Reviews
09/06/2021

    Superior quality, highly recommend.

    01/23/2020

      Worked well, as described.

      01/08/2020

        Perfect for protein studies.

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