Active Recombinant Human CYR61 Protein, Fc Chimera
Cat.No. : | CYR61-895H |
Product Overview : | Recombinant Human CYR61 (Accession # O00622), fused with , was produced in Chinese Hamster Ovary cell line, CHO-derived. |
- Specification
- Gene Information
- Related Products
Source : | CHO Cells |
Species : | Human |
Tag : | Fc |
Predicted N Terminal : | Ala22 |
Form : | Lyophilized from a 0.2 µm filtered solution in PBS and NaCl. |
Bio-activity : | Measured by its ability to mediate Balb/3T3 mouse embryonic fibroblast cell adhesion. Ball, D.K. et al. (2003) Reproduction 125:271. Recombinant Human Cyr61/CCN1 Fc Chimera immobilized at 1.5 µg/mL, 100 µL/well, will mediate >25% BALB/3T3 cell adhesion (3 x 10^4 cell/well added). |
Molecular Mass : | Recombinant Human CYR61, Fc Chimera has a calculated MW of 66.3 kDa. In SDS-PAGE migrates as 70-75 kDa, reducing conditions. |
Purity : | >90%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
Storage : | Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC). |
Gene Name : | CYR61 cysteine-rich, angiogenic inducer, 61 [ Homo sapiens ] |
Official Symbol : | CYR61 |
Synonyms : | CYR61; cysteine-rich, angiogenic inducer, 61; IGFBP10; protein CYR61; CCN1; GIG1; IBP-10; IGFBP-10; CCN family member 1; IGF-binding protein 10; cysteine-rich, anigogenic inducer, 61; cysteine-rich heparin-binding protein 61; insulin-like growth factor-binding protein 10; |
Gene ID : | 3491 |
mRNA Refseq : | NM_001554 |
Protein Refseq : | NP_001545 |
MIM : | 602369 |
UniProt ID : | O00622 |
Chromosome Location : | 1p22.3 |
Products Types
◆ Recombinant Protein | ||
Cyr61-437M | Recombinant Mouse Cyr61 Protein, His-tagged | +Inquiry |
CYR61-1374M | Recombinant Mouse CYR61 Protein (25-379 aa), His-tagged | +Inquiry |
CYR61-436H | Recombinant Human CYR61 Protein, His-tagged | +Inquiry |
CYR61-2295H | Recombinant Human CYR61 Protein, GST-tagged | +Inquiry |
CYR61-2165M | Recombinant Mouse CYR61 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CYR61-7097HCL | Recombinant Human CYR61 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionRecent studies have found that CYR61 plays an important role in tumor development and metastasis, especially in cancers such as non-small cell lung cancer, breast cancer, gastric cancer, and colorectal cancer.
There are currently no drugs specifically targeting CYR61, but some anti-tumor drugs can inhibit the expression level of CYR61, such as chemotherapy drugs and targeted therapy drugs.
Studies have shown that high levels of CYR61 expression are associated with decreased patient survival, suggesting that it may be used as a biomarker to predict patient survival.
CYR61 is involved in a variety of signaling pathways, including Wnt, MAPK, ERK, and PI3K.
Regulating the expression level of CYR61 is of great significance for the treatment of diseases, especially for the treatment of cancer, and can slow down the growth and spread of tumors by inhibiting the expression level of CYR61.
The relationship between CYR61 expression levels and disease risk can be assessed by immunohistochemistry or western blot analysis of the patient's tissue samples.
Customer Reviews (3)
Write a reviewIt has good effect and stability in gene expression regulation.
Will not interact with other drugs, will not affect.
The application performance is stable in common colorimetric reactions.
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