Recombinant Human DCK Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: DCK-734H
• Product Overview: DCK MS Standard C13 and N15-labeled recombinant protein (NP_000779) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 30.5 kDa
• AA Sequence: MATPPKRSCPSFSASSEGTRIKKIS IEGNIAAGKSTFVNILKQLCEDWEV VPEPVARWCNVQSTQDEFEELTMSQ KNGGNVLQMMYEKPERWSFTFQTYA CLSRIRAQLASLNGKLKDAEKPVLF FERSVYSDRYIFASNLYESECMNET EWTIYQDWHDWMNNQFGQSLELDGI IYLQATPETCLHRIYLRGRNEEQGI PLEYLEKLHYKHESWLLHRTLKTNF DYLQEVPILTLDVNEDFKDKYESLV EKVKEFLSTLTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: DCK deoxycytidine kinase [ Homo sapiens (human) ]
• Official Symbol: DCK
• Synonyms: DCK; deoxycytidine kinase; deoxynucleoside kinase; MGC117410; MGC138632
• Gene ID: 1633
• mRNA Refseq: NM_000788
• Protein Refseq: NP_000779
• MIM: 125450
• UniProt ID: P27707